INT114180

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 11.06
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
joint 1
liver 1
Spleen 1
Il1rn (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 25 100.00 Very High Very High Very High
Paracetamol 16 99.92 Very High Very High Very High
withdrawal 5 99.80 Very High Very High Very High
Arthritis 203 99.46 Very High Very High Very High
Potency 38 99.16 Very High Very High Very High
Inflammation 120 98.68 Very High Very High Very High
Cholecystokinin 12 98.68 Very High Very High Very High
agonist 26 97.80 Very High Very High Very High
cytokine 120 97.36 Very High Very High Very High
Dynorphin 12 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 8 99.88 Very High Very High Very High
Cognitive Disorder 108 99.84 Very High Very High Very High
Obesity 53 99.72 Very High Very High Very High
Injury 8 99.60 Very High Very High Very High
Arthritis 203 99.46 Very High Very High Very High
Targeted Disruption 78 99.12 Very High Very High Very High
Syndrome 11 98.88 Very High Very High Very High
INFLAMMATION 109 98.68 Very High Very High Very High
Systemic Lupus Erythematosus 43 98.60 Very High Very High Very High
Hypercalcemia 3 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is supported by the fact that IL-1Ra and IL-10 response after LPS exposure is decreased in Ob/Ob mice [55], although we observed higher levels of IL-1Ra and IL-10 in HFD-fed obese mice in the present study.
Negative_regulation (decreased) of IL-1Ra associated with obesity
1) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.89 Pain Relevance 0
Although IRAP was cloned more than a decade ago, the first and only specific, high affinity inhibitors of IRAP that are used to investigate the physiological roles of the enzyme are the peptides Ang IV and LVV-H7.
Negative_regulation (inhibitors) of IRAP
2) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.25 Pain Relevance 0.31
There are separate but overlapping collections of data that assess either competition binding to membrane fractions, or inhibition of IRAP catalytic activity; there is clear evidence that these two measures do not correlate.
Negative_regulation (inhibition) of IRAP
3) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0 Pain Relevance 0.03
Our discovery that peptide inhibitors of insulin-regulated aminopeptidase (IRAP) elicit significant effects on memory acquisition and retrieval provides the basis for the proposition that IRAP is a novel target for the discovery of cognitive enhancers.
Negative_regulation (inhibitors) of IRAP associated with cognitive disorder
4) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.82 Pain Relevance 0.09
Peptide inhibitors of IRAP
Negative_regulation (inhibitors) of IRAP
5) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.13 Pain Relevance 0.24
The available data relating to inhibition of IRAP (summarized in Table 1) point to a primary pharmacophore centred on the VYI/VYP motifs of the parent peptides.
Negative_regulation (inhibition) of IRAP
6) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0 Pain Relevance 0.03
Design of inhibitors of IRAP based on the known peptide inhibitors
Negative_regulation (inhibitors) of IRAP
7) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0 Pain Relevance 0.03
Unfortunately, no data are available describing IRAP inhibition of these compounds.
Negative_regulation (inhibition) of IRAP
8) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0 Pain Relevance 0.13
Development of inhibitors of IRAP as cognitive enhancers
Negative_regulation (inhibitors) of IRAP associated with cognitive disorder
9) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.26 Pain Relevance 0.32
The two archetypal competitive inhibitors of IRAP are the peptides Ang IV (VYIHPF) and LVV-H7 (LVVYPWTQRF), with Ki values of 113 nM and 845 nM, respectively [21].
Negative_regulation (inhibitors) of IRAP
10) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.12 Pain Relevance 0.23
Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist.
Negative_regulation (disruption) of IL-1 receptor antagonist in liver associated with paracetamol, antagonist and injury
11) Confidence 0.38 Published 2009 Journal Lab. Invest. Section Title Doc Link 19002106 Disease Relevance 0.19 Pain Relevance 0.98
The fundamental discovery of peptide inhibitors of IRAP and their ability to enhance memory underpins this research.
Negative_regulation (inhibitors) of IRAP
12) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.38 Pain Relevance 0
In silico-derived IRAP inhibitors
Negative_regulation (inhibitors) of IRAP
13) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0 Pain Relevance 0.12
Furthermore, Ang IV and LVV-H7 were found to be competitive inhibitors of IRAP, inhibiting its aminopeptidase activity by binding to the catalytic site [20,21].
Negative_regulation (inhibitors) of IRAP
14) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.25 Pain Relevance 0.27
Mice or rats with lupus-like syndrome, transgenic HLA-B27 expression, nonobese diabetes, and interleukin-1 receptor antagonist (IL-1Ra) deficiency belong to the first category, whereas those with collagen-induced arthritis or experimental autoimmune encephalomyelitis (EAE) as models of RA and multiple sclerosis (MS), respectively, belong to the second category.
Negative_regulation (deficiency) of IL-1Ra associated with diabetes mellitus, syndrome, rheumatoid arthritis, systemic lupus erythematosus, targeted disruption, multiple sclerosis, antagonist and arthritis
15) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592775 Disease Relevance 1.62 Pain Relevance 0.24
Mice or rats with lupus-like syndrome, transgenic HLA-B27 expression, nonobese diabetes, and interleukin-1 receptor antagonist (IL-1Ra) deficiency belong to the first category, whereas those with collagen-induced arthritis or experimental autoimmune encephalomyelitis (EAE) as models of RA and multiple sclerosis (MS), respectively, belong to the second category.
Negative_regulation (deficiency) of interleukin-1 receptor antagonist associated with diabetes mellitus, syndrome, rheumatoid arthritis, systemic lupus erythematosus, targeted disruption, multiple sclerosis, antagonist and arthritis
16) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592775 Disease Relevance 1.68 Pain Relevance 0.24
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Negative_regulation (decreased) of IL-1Ra in Spleen associated with withdrawal
17) Confidence 0.15 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.49
In other studies, BALB/c mice lacking IL-1ra spontaneously developed chronic inflammatory polyarthropathy, with joint pathology closely resembling that of RA [32].
Negative_regulation (lacking) of IL-1ra in joint associated with inflammation and rheumatoid arthritis
18) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.29 Pain Relevance 0.61
Further support for the crucial role of IL-1 emerged from the recent demonstration of spontaneous arthritis in Balb/c mice, which are deficient in IL-1ra [48].
Negative_regulation (deficient) of IL-1ra associated with arthritis
19) Confidence 0.06 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 1.12 Pain Relevance 0.51
Hypernociception induced by antigen was reduced in animals pretreated with IL-1ra and reparixin (a non-competitive allosteric inhibitor of CXCR2), and in TNF receptor type 1 deficient (TNFR1-/-) mice.
Negative_regulation (inhibitor) of IL-1ra
20) Confidence 0.02 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.24 Pain Relevance 0.18

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