INT114183

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 11.31
Pain Relevance 4.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1rn) extracellular region (Il1rn) nucleus (Il1rn)
lipid metabolic process (Il1rn) cytoplasm (Il1rn)
Anatomy Link Frequency
macrophage 1
plasma 1
liver 1
fat 1
brain 1
Il1rn (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 490 100.00 Very High Very High Very High
Inflammation 355 100.00 Very High Very High Very High
antagonist 23 100.00 Very High Very High Very High
withdrawal 6 99.04 Very High Very High Very High
ischemia 83 96.48 Very High Very High Very High
rheumatoid arthritis 134 94.64 High High
Arthritis 144 88.80 High High
Morphine 3 86.80 High High
Hippocampus 38 74.56 Quite High
Inflammatory mediators 26 70.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 443 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 70 100.00 Very High Very High Very High
Brain Injury 29 99.92 Very High Very High Very High
Stroke 166 99.60 Very High Very High Very High
Obesity 206 99.30 Very High Very High Very High
Injury 156 99.04 Very High Very High Very High
Necrosis 198 98.44 Very High Very High Very High
Cv Unclassified Under Development 53 96.48 Very High Very High Very High
Drug Induced Neurotoxicity 20 96.20 Very High Very High Very High
Rheumatoid Arthritis 139 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The plasma level of IRAP is increased during the later stages of pregnancy and it is thought that this enzyme is involved in the regulation of circulating oxytocin to prevent the onset of premature labour [43].
Positive_regulation (increased) of IRAP in plasma associated with pre-term labor
1) Confidence 0.55 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604898 Disease Relevance 0.16 Pain Relevance 0.03
The relative increase in Il1rn mRNA (HFD versus LFD) was 155-fold in uninfected and only 13-fold in infected mice (Fig. 3A).
Positive_regulation (increase) of Il1rn
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.47 Pain Relevance 0.28
This is supported by the fact that IL-1Ra and IL-10 response after LPS exposure is decreased in Ob/Ob mice [55], although we observed higher levels of IL-1Ra and IL-10 in HFD-fed obese mice in the present study.
Positive_regulation (levels) of IL-1Ra associated with obesity
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.90 Pain Relevance 0
The anti-inflammatory cytokine IL-1Ra was increased in serum and fat in both uninfected and infected HFD-fed mice compared with LFD-fed mice.
Positive_regulation (increased) of cytokine IL-1Ra in fat associated with inflammation and cytokine
4) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.77 Pain Relevance 0.36
In liver we also found an increase in Il1rn (P?
Positive_regulation (increase) of Il1rn in liver
5) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.51 Pain Relevance 0.56
In uninfected mice the only difference was seen in the levels of the anti-inflammatory cytokine IL-1Ra, which were increased in HFD-fed mice (169 (range: 33–1111) and 1587 (range: 84–32245) pg ml?
Positive_regulation (increased) of cytokine IL-1Ra associated with inflammation and cytokine
6) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 0.77 Pain Relevance 0.41
Many immune-related genes showed upregulation in the SLE patients, including the IL-1 family members IL1B, IL1R2, and IL-1 receptor antagonist (IL1RN).
Positive_regulation (upregulation) of IL1RN associated with antagonist and systemic lupus erythematosus
7) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.13 Pain Relevance 0.13
and IL-6 were comparable with the wild type mice that received IL-1Ra treatment (Figures 2a and 2b; P < 0.0001, P < 0.001 vs LPS).
Positive_regulation (received) of IL-1Ra
8) Confidence 0.21 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.20 Pain Relevance 0.24
Interestingly, IL-1Ra treatment had no effects on HMGB-1 levels, which maintained a similar pattern to that seen after LPS injection in the absence of IL-1Ra (Figure 2c).
Positive_regulation (absence) of IL-1Ra
9) Confidence 0.19 Published 2010 Journal Crit Care Section Body Doc Link PMC2911722 Disease Relevance 0.27 Pain Relevance 0.30
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Positive_regulation (levels) of IL-1Ra in Spleen associated with withdrawal
10) Confidence 0.17 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.49
, to be a significant in vivo and in vitro stimulus for murine IL-1ra production [24].
Positive_regulation (stimulus) of IL-1ra
11) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.59 Pain Relevance 0.35
In addition, the levels of cytokines in the hAFSC treated ATN mice, compared with basal nu/nu mouse kidney levels showed that there was an increase of anti-inflammatory cytokines such as IL-10 and IL-1Ra (Table S1).
Positive_regulation (increase) of IL-1Ra in kidney associated with necrosis, inflammation and cytokine
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0.94 Pain Relevance 0.47
will lead to increased levels of IL-1ra, an antagonist of IL-1?.
Positive_regulation (increased) of IL-1ra associated with antagonist
13) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.53 Pain Relevance 0.33
and IL-1ra is more important than the levels of IL-1?
Positive_regulation (important) of IL-1ra
14) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.56 Pain Relevance 0.34
IL-1Ra increased significantly during the first year in both study groups, but the rise was not sustained until the end of the trial.
Positive_regulation (increased) of IL-1Ra
15) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165058 Disease Relevance 0.20 Pain Relevance 0.14
Increased levels of endogenous IL-1ra and IL-1RII are likely to be important mechanisms for regulation of IL-1 activity following brain injury.
Positive_regulation (Increased) of IL-1ra in brain associated with brain injury
16) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.35 Pain Relevance 0.13
IL-1ra is rapidly induced following experimental injury, and blockade of endogenous production leads to exacerbation of neurotoxicity following ischemic injury in rodents [74,79].
Positive_regulation (induced) of IL-1ra associated with drug induced neurotoxicity and injury
17) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2335091 Disease Relevance 1.24 Pain Relevance 0.09
In addition, in these mice, there was an increase of levels in IL-10 and IL-1Ra and IL-6 following hAFSC injection (similar to that noted in the mice injected with hAFSC following ATN), there was no increase in SDF-1 and also they expressed lower levels of NK attractors as well as macrophage attractors.
Positive_regulation (increase) of IL-1Ra in macrophage associated with necrosis
18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 0.60 Pain Relevance 0.18

General Comments

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