INT114188

Context Info Confidence 0.41 First Reported 2003 Last Reported 2011 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 3.69 Pain Relevance 2.53

extracellular region (Cort)

Anatomy Link Frequency plasma 1 Cort (Mus musculus)

Pain Link Frequency Relevance Heat corticosteroid 19 100.00 Desipramine 2 99.40 fluoxetine 5 99.08 Buprenorphine 14 97.92 Neuropeptide 1 92.96 tricyclic antidepressant 3 89.08 sSRI 3 87.84 cytokine 3 83.04 Opioid 2 81.36 Eae 22 78.36

Disease Link Frequency Relevance Heat Alopecia Areata 8 99.52 Targeted Disruption 78 99.06 Stress 105 98.80 Necrosis 1 81.84 Cancer 1 81.48 Depression 17 72.16 Aggression 30 71.60 Convulsion 2 69.84 Congenital Anomalies 3 50.00 Hypersensitivity 3 46.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Fluoxetine and desipramine administration significantly attenuated plasma ACTH and CORT levels in male and female Avpr1b KO mice when compared to their wild-type counterparts.

Negative_regulation (attenuated) of CORT in plasma associated with targeted disruption, desipramine and fluoxetine

1) Confidence 0.41 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.64 Pain Relevance 0.92

Morphine at higher doses (30 and 60 mg/kg) significantly decreased CST in males and diestrus females, with less relative effect in estrus mice.

Negative_regulation (decreased) of CST

2) Confidence 0.38 Published 2004 Journal Epilepsia Section Body Doc Link 15329066 Disease Relevance 0.07 Pain Relevance 0

Results show that buprenorphine, delivered by osmotic pump subcutaneously in C57BL/6 male mice during a 10-day period, caused a marked decrease in total corticosterone (CORT) levels at day 1 of exposure.

Negative_regulation (decrease) of CORT associated with buprenorphine

3) Confidence 0.28 Published 2003 Journal Clin. Immunol. Section Abstract Doc Link 14597216 Disease Relevance 0 Pain Relevance 0.50

After day 5, total CORT levels gradually decreased and returned to control values.

Negative_regulation (decreased) of CORT

4) Confidence 0.28 Published 2003 Journal Clin. Immunol. Section Abstract Doc Link 14597216 Disease Relevance 0 Pain Relevance 0.60

Basal CORT levels were significantly decreased in KO animals compared with WT in the morning as well as in the evening.

Negative_regulation (decreased) of CORT associated with corticosteroid

5) Confidence 0.27 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.58 Pain Relevance 0.41

AA mice had significantly blunted CORT and ACTH responses to acute ether stress (physiological stressor) and a deficit in habituation to repeated restraint stress (psychological stressor).

Negative_regulation (blunted) of CORT associated with stress and alopecia areata

6) Confidence 0.23 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 19020552 Disease Relevance 1.10 Pain Relevance 0.10

These studies have a number of salient features: firstly, as observed in male Brattleboro rats subjected to repeated restraint (Zelena et al. 2004), the reduction in the ACTH response following repeated stress in Avpr1b KO animals is not often accompanied by a similar reduction in CORT responses—this mirrors what we have observed in these animals' responses to acute stress (see above).

Negative_regulation (reduction) of CORT associated with targeted disruption and stress

7) Confidence 0.22 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 1.30 Pain Relevance 0

General Comments

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