INT114199

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.71
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc32a1)
Anatomy Link Frequency
developmental stages 2
Slc32a1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 85 100.00 Very High Very High Very High
GABAergic 30 98.68 Very High Very High Very High
Morphine 8 98.32 Very High Very High Very High
withdrawal 3 95.08 Very High Very High Very High
Spinal cord 32 88.40 High High
addiction 2 87.52 High High
Neurotransmitter 12 70.00 Quite High
narcan 2 69.60 Quite High
Central nervous system 10 68.72 Quite High
Glutamate 14 68.64 Quite High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 3 95.08 Very High Very High Very High
Targeted Disruption 73 94.88 High High
Morphine Dependence 2 87.52 High High
Umbilical Hernia 48 78.52 Quite High
Cleft Palate 32 77.92 Quite High
Pain 2 39.16 Quite Low
Anxiety Disorder 6 37.88 Quite Low
Convulsion 2 37.16 Quite Low
Generalized Anxiety Disorder 6 32.40 Quite Low
Cognitive Disorder 2 13.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the VGAT-floxneo allele allowed for Cre-mediated conditional inactivation of the VGAT gene, and mice carrying these alleles will be useful in examining VGAT function at different developmental stages and in distinct cell types.


Positive_regulation (allowed) of Gene_expression (allele) of VGAT-floxneo in developmental stages
1) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.62 Pain Relevance 0.21
Generation of VGAT-/- mice
Positive_regulation (Generation) of Gene_expression (Generation) of VGAT
2) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.71 Pain Relevance 0.18
We generated GABA transporter I (GAT1)-overexpressing mice to investigate whether the GABAergic system and GABA transporter are involved in morphine-induced reward effects and withdrawal symptoms.
Positive_regulation (-overexpressing) of Gene_expression (overexpressing) of GABA transporter associated with gaba, gabaergic, withdrawal and morphine
3) Confidence 0.24 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14598306 Disease Relevance 0.38 Pain Relevance 0.96

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox