INT114199

Context Info Confidence 0.44 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.71 Pain Relevance 1.35

transport (Slc32a1)

Anatomy Link Frequency developmental stages 2 Slc32a1 (Mus musculus)

Pain Link Frequency Relevance Heat gABA 85 100.00 GABAergic 30 98.68 Morphine 8 98.32 withdrawal 3 95.08 Spinal cord 32 88.40 addiction 2 87.52 Neurotransmitter 12 70.00 narcan 2 69.60 Central nervous system 10 68.72 Glutamate 14 68.64

Disease Link Frequency Relevance Heat Substance Withdrawal Syndrome 3 95.08 Targeted Disruption 73 94.88 Morphine Dependence 2 87.52 Umbilical Hernia 48 78.52 Cleft Palate 32 77.92 Pain 2 39.16 Anxiety Disorder 6 37.88 Convulsion 2 37.16 Generalized Anxiety Disorder 6 32.40 Cognitive Disorder 2 13.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, the VGAT-floxneo allele allowed for Cre-mediated conditional inactivation of the VGAT gene, and mice carrying these alleles will be useful in examining VGAT function at different developmental stages and in distinct cell types.

Positive_regulation (allowed) of Gene_expression (allele) of VGAT-floxneo in developmental stages

1) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.62 Pain Relevance 0.21

Generation of VGAT-/- mice

Positive_regulation (Generation) of Gene_expression (Generation) of VGAT

2) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.71 Pain Relevance 0.18

We generated GABA transporter I (GAT1)-overexpressing mice to investigate whether the GABAergic system and GABA transporter are involved in morphine-induced reward effects and withdrawal symptoms.

Positive_regulation (-overexpressing) of Gene_expression (overexpressing) of GABA transporter associated with gaba, gabaergic, withdrawal and morphine

3) Confidence 0.24 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14598306 Disease Relevance 0.38 Pain Relevance 0.96

General Comments

This test has worked.