INT114218

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2006
Negated 2
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.43
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Wt1) nucleolus (Wt1) RNA binding (Wt1)
nucleus (Wt1) intracellular (Wt1) cytoplasm (Wt1)
Anatomy Link Frequency
podocyte 7
Wt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 7 89.44 High High
imagery 6 58.32 Quite High
Disease Link Frequency Relevance Heat
Wilms Tumor 1 100.00 Very High Very High Very High
Diabetes Mellitus 468 99.04 Very High Very High Very High
Albuminuria 87 94.24 High High
Experimental Diabetes Mellitus 6 86.52 High High
Diabetic Nephropathy 108 85.12 High High
Injury 38 75.68 Quite High
Hypertrophy 2 75.00 Quite High
Diabetes Complications 12 71.76 Quite High
Hyperglycemia 24 61.32 Quite High
Renal Disease 42 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of proliferating cellular antigen (PCNA), cyclin-dependent kinase inhibitor p27, Wilms tumor gene (WT1), and desmin, a marker of early podocyte damage, was investigated by immunohistology.
Spec (investigated) Gene_expression (expression) of WT1 in podocyte associated with wilms tumor
1) Confidence 0.62 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 14600034 Disease Relevance 0.35 Pain Relevance 0.09
However, as they also noted, there are no data to indicate that podocytes in DN are WT-1 negative.
Neg (negative) Gene_expression (negative) of WT-1 in podocytes
2) Confidence 0.52 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1435876 Disease Relevance 0.33 Pain Relevance 0
In addition, WT-1 is an excellent marker of the normal mature differentiated podocyte and even podocytes with effaced foot processes remain WT-1 positive.
Gene_expression (positive) of WT-1 in podocytes
3) Confidence 0.52 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1435876 Disease Relevance 0.33 Pain Relevance 0
Using an ABC Staining Kit (Vector Laboratory Inc., Dedham, MA), podocyte nuclei were detected with a rabbit polyclonal or a mouse monoclonal anti-WT1 antibody (SantaCruz Biotechnology, Inc., Santa Cruz, CA) at a concentration of 2 ?
Gene_expression (antibody) of WT1 in podocyte
4) Confidence 0.52 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1435876 Disease Relevance 0 Pain Relevance 0.08
The number of podocytes per glomerular section and the podocyte density in glomeruli from rats and mice with streptozotocin (STZ)-diabetes mellitus was determined at several time points based on detection of the glomerular podocyte specific antigens, WT-1 and GLEPP1.
Gene_expression (detection) of WT-1 in podocyte associated with diabetes mellitus
5) Confidence 0.47 Published 2006 Journal BMC Nephrol Section Abstract Doc Link PMC1435876 Disease Relevance 0.85 Pain Relevance 0
In addition, WT-1 is an excellent marker of the normal mature differentiated podocyte and even podocytes with effaced foot processes remain WT-1 positive.
Gene_expression (positive) of WT-1 in podocytes
6) Confidence 0.46 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1435876 Disease Relevance 0.31 Pain Relevance 0
Hence, if a podocyte is WT-1 negative, then it is likely to be severely and perhaps terminally damaged.
Neg (negative) Gene_expression (negative) of WT-1 in podocyte
7) Confidence 0.46 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1435876 Disease Relevance 0.26 Pain Relevance 0

General Comments

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