INT114220

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 4.11
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) cell death (Cdkn1b) nucleus (Cdkn1b)
cell cycle (Cdkn1b) protein complex (Cdkn1b) response to stress (Cdkn1b)
Anatomy Link Frequency
colon 4
podocyte 2
Cdkn1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 10 84.04 Quite High
Inflammation 11 79.92 Quite High
Pain 2 78.68 Quite High
anesthesia 2 50.52 Quite High
Central nervous system 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Retinopathy 14 99.84 Very High Very High Very High
Renal Disease 4 99.28 Very High Very High Very High
Injury 3 98.92 Very High Very High Very High
Cancer 2 96.80 Very High Very High Very High
Colon Cancer 12 95.16 Very High Very High Very High
Albuminuria 4 93.56 High High
Hypertension 31 92.56 High High
Hypertrophy 4 91.36 High High
Aberrant Crypt Foci 2 91.00 High High
Diabetes Mellitus 93 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of a reduction in p27Kip1 expression on diabetic retinopathy remains to be elucidated.
Negative_regulation (reduction) of Gene_expression (expression) of p27Kip1 associated with diabetic retinopathy
1) Confidence 0.33 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.45 Pain Relevance 0
In parallel, the increase in podocyte volume in SNX+solvent rats was abrogated by treatment with 1,25(OH)(2)D(3), and immunohistochemistry revealed less expression of desmin, PCNA, and p27, suggesting less podocyte injury and activation of the cyclin cascade.
Negative_regulation (revealed) of Gene_expression (expression) of p27 in podocyte associated with injury
2) Confidence 0.29 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 14600034 Disease Relevance 0.45 Pain Relevance 0.05
Analysis of proximal and distal colon tissue from 8- and 28-week rat/azoxymethane studies showed that GT-094 treatment reduced colon crypt proliferation by 30% to 69%, reduced inducible NO synthase (iNOS) levels by 33% to 67%, reduced poly(ADP-ribose)polymerase-1 expression and cleavage 2- to 4-fold, and elevated levels of p27 in the distal colon 3-fold.
Negative_regulation (reduced) of Gene_expression (expression) of p27 in colon
3) Confidence 0.24 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17699720 Disease Relevance 1.10 Pain Relevance 0.59
Analysis of proximal and distal colon tissue from 8- and 28-week rat/azoxymethane studies showed that GT-094 treatment reduced colon crypt proliferation by 30% to 69%, reduced inducible NO synthase (iNOS) levels by 33% to 67%, reduced poly(ADP-ribose)polymerase-1 expression and cleavage 2- to 4-fold, and elevated levels of p27 in the distal colon 3-fold.
Negative_regulation (reduced) of Gene_expression (expression) of p27 in colon
4) Confidence 0.24 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17699720 Disease Relevance 1.11 Pain Relevance 0.60

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox