INT114230

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Context Info
Confidence 0.13
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.61
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1I2) signal transduction (NR1I2) small molecule metabolic process (CYP2C9)
oxidoreductase activity (CYP2C9) endoplasmic reticulum (CYP2C9) nucleus (NR1I2)
NR1I2 (Homo sapiens)
CYP2C9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 91.40 High High
anticonvulsant 3 85.48 High High
Disease Link Frequency Relevance Heat
Non-genital Cutaneous Warts 3 94.56 High High
INFLAMMATION 3 91.16 High High
Hypertension 3 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrate that the human pregnane X receptor (hPXR) mediates induction of CYP2C9 by the prototype drugs rifampicin, hyperforin (found in St.
hPXR Positive_regulation (mediates) of Positive_regulation (induction) of CYP2C9
1) Confidence 0.13 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600250 Disease Relevance 0.27 Pain Relevance 0.13
In the present study, we demonstrate that the human pregnane X receptor (hPXR) mediates induction of CYP2C9 by the prototype drugs rifampicin, hyperforin (found in St.
pregnane X receptor Positive_regulation (mediates) of Positive_regulation (induction) of CYP2C9
2) Confidence 0.12 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600250 Disease Relevance 0.27 Pain Relevance 0.13
This is the first report to demonstrate that the nuclear receptor PXR mediates induction of CYP2C9 with rifampicin, phenobarbital, and hyperforin.
nuclear receptor PXR Positive_regulation (mediates) of Positive_regulation (induction) of CYP2C9
3) Confidence 0.12 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14600250 Disease Relevance 0.06 Pain Relevance 0

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