INT114243

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.06
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 5 95.28 Very High Very High Very High
cINOD 3 91.68 High High
Antinociceptive 1 88.12 High High
qutenza 4 85.20 High High
dexamethasone 1 82.92 Quite High
COX-2 inhibitor 2 82.20 Quite High
Calcitonin gene-related peptide 4 81.68 Quite High
Inflammation 6 80.28 Quite High
Pain 2 79.60 Quite High
acular 2 72.48 Quite High
Disease Link Frequency Relevance Heat
Stress 43 100.00 Very High Very High Very High
Alzheimer's Dementia 4 99.80 Very High Very High Very High
Apoptosis 64 99.12 Very High Very High Very High
Drug Induced Neurotoxicity 1 98.80 Very High Very High Very High
Hyperalgesia 5 95.28 Very High Very High Very High
Nociception 4 94.20 High High
Neuroblastoma 1 89.20 High High
INFLAMMATION 7 82.48 Quite High
Injury 70 81.28 Quite High
Pain 2 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that induction of COX-2 by proinflammatory mediators and subsequent release of prostaglandins could be responsible for LPS enhancement of formalin-induced nocifensive behaviour and supports an important role of COX-2 in LPS-induced hyperalgesia in the formalin test.
Positive_regulation (responsible) of Positive_regulation (induction) of COX associated with hyperalgesia
1) Confidence 0.39 Published 2005 Journal Indian J. Exp. Biol. Section Abstract Doc Link 15691066 Disease Relevance 0.46 Pain Relevance 0.49
As an underlying mechanism of COX-2 inhibition, these extracts diminished TPA-stimulated catalytic activity of extracellular signal-regulated protein kinase (ERK), which is known to regulate the activation of eukaryotic transcription factors mediating COX-2 induction.
Positive_regulation (mediating) of Positive_regulation (induction) of COX
2) Confidence 0.18 Published 2005 Journal Cancer Lett. Section Abstract Doc Link 15639337 Disease Relevance 0.37 Pain Relevance 0.19
H/R significantly increased oxidative stress, induction of COX-1 and COX-2, and the apoptotic index.
Positive_regulation (increased) of Positive_regulation (induction) of COX associated with stress and apoptosis
3) Confidence 0.09 Published 2007 Journal Placenta Section Abstract Doc Link PMC1895600 Disease Relevance 1.25 Pain Relevance 0
COX-1 selective inhibitors provided greater protection than did COX-2 selective inhibitors or lipoxygenase inhibitors, suggesting that activation of COX-1 is required for amyloid-beta1-42-induced neurotoxicity.
Positive_regulation (required) of Positive_regulation (activation) of COX associated with drug induced neurotoxicity and alzheimer's dementia
4) Confidence 0.07 Published 2003 Journal Neuroreport Section Abstract Doc Link 14600505 Disease Relevance 0.71 Pain Relevance 0.26
Thus, the EGF-R signal appears to mediate COX-2 induction in the gastric mucosa.
Spec (appears) Positive_regulation (mediate) of Spec (appears) Positive_regulation (induction) of COX
5) Confidence 0.05 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1552080 Disease Relevance 0.26 Pain Relevance 0.25

General Comments

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