INT114263

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.71
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 2
osteoblast 2
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 10 100.00 Very High Very High Very High
Antinociceptive 31 99.80 Very High Very High Very High
Calcitonin gene-related peptide 7 98.84 Very High Very High Very High
substance P 5 98.48 Very High Very High Very High
Paracetamol 92 97.96 Very High Very High Very High
antinociception 12 97.60 Very High Very High Very High
Analgesic 16 94.40 High High
qutenza 16 93.76 High High
ischemia 5 90.00 High High
Eae 6 82.72 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 11 99.96 Very High Very High Very High
Hypercalcemia 3 99.44 Very High Very High Very High
Death 5 94.88 High High
Coronary Artery Disease 2 90.88 High High
Targeted Disruption 6 87.36 High High
Apoptosis 1 85.08 High High
Nociception 31 83.52 Quite High
Inflammatory Pain 3 82.72 Quite High
Urological Neuroanatomy 3 80.56 Quite High
Cv Unclassified Under Development 4 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that disruption of the calmodulin binding segment prevented TRPV1 desensitization even in the presence of extracellular Ca2+.
Negative_regulation (prevented) of Negative_regulation (desensitization) of TRPV1
1) Confidence 0.43 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469041 Disease Relevance 0.18 Pain Relevance 0.40
Moreover, the capsaicin-induced desensitization of TRPV1 was markedly attenuated in the presence of propofol in neurons from wild-type mice but not in neurons from PKCepsilon-null mice.
Neg (not) Negative_regulation (attenuated) of Negative_regulation (desensitization) of TRPV1 in neurons
2) Confidence 0.43 Published 2010 Journal Anesthesiology Section Body Doc Link 20808213 Disease Relevance 0.07 Pain Relevance 0
These results demonstrate that capsazepine affords neuroprotection through inhibition of I(h) rather than inhibition of VR1.
Negative_regulation (inhibition) of Negative_regulation (inhibition) of VR1
3) Confidence 0.43 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14602831 Disease Relevance 0.42 Pain Relevance 0.12
Importantly, inhibition of TRPV1 by an intracerebroventricular injection of capsazepine abolished the antinociceptive effect of orally administered acetaminophen, supporting the view that acetaminophen has a central site of action [10], [27].
Negative_regulation (abolished) of Negative_regulation (inhibition) of TRPV1 associated with paracetamol, antinociceptive and intracerebroventricular
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941447 Disease Relevance 0.31 Pain Relevance 1.51
We conclude that pharmacological blockade of TRPV1 ion channels by capsazepine inhibits osteoclastic bone resorption and protects against ovariectomy induced bone loss in mice, but also inhibits osteoblast activity and bone formation.
Negative_regulation (inhibits) of Negative_regulation (blockade) of TRPV1 in osteoblast associated with hypercalcemia and osteoporosis
5) Confidence 0.41 Published 2010 Journal Bone Section Abstract Doc Link 20096813 Disease Relevance 1.37 Pain Relevance 0.27
We propose that reduction of PG levels may contribute to deleterious vascular effects by decreasing sensitization of TRPV1 and subsequent reduction of CGRP and SP release.
Negative_regulation (decreasing) of Negative_regulation (sensitization) of TRPV1 associated with substance p and calcitonin gene-related peptide
6) Confidence 0.30 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.38 Pain Relevance 0.62

General Comments

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