INT114270

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.33
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Plscr1) Golgi apparatus (Plscr1) nucleolus (Plscr1)
plasma membrane (Plscr1) nucleus (Plscr1) enzyme binding (Plscr1)
Anatomy Link Frequency
nucleus accumbens 1
striatum 1
eosinophil 1
prefrontal 1
Plscr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 1 100.00 Very High Very High Very High
Dopamine 15 98.76 Very High Very High Very High
midbrain 4 98.40 Very High Very High Very High
Nucleus accumbens 8 98.08 Very High Very High Very High
agonist 3 97.00 Very High Very High Very High
Enkephalin 6 92.80 High High
antagonist 2 92.24 High High
Neuropeptide 4 81.32 Quite High
Nerve growth factor 1 81.00 Quite High
corticosteroid 5 53.20 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 77 100.00 Very High Very High Very High
Catalepsy 2 89.68 High High
Psychosis 4 87.44 High High
Targeted Disruption 11 85.64 High High
Lymphatic System Cancer 2 77.72 Quite High
Diffuse Large B-cell Lymphoma 1 76.64 Quite High
INFLAMMATION 16 41.20 Quite Low
Asthma 24 39.28 Quite Low
Fibrosis 2 31.36 Quite Low
Airway Remodeling 2 28.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nur77 and Nor-1 are expressed in dopaminoceptive areas such as the striatum, nucleus accumbens, and prefrontal cortex.
Gene_expression (expressed) of Nor-1 in striatum associated with nucleus accumbens
1) Confidence 0.47 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0 Pain Relevance 0.20
Modulation of Nur77 and Nor-1 mRNA expression by antipsychotics can be used to calculate an index that is predictive of the typical or atypical profile of antipsychotic drugs.
Gene_expression (expression) of Nor-1
2) Confidence 0.36 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.09 Pain Relevance 0.27
Nur77 and Nor-1 are expressed in dopaminoceptive areas such as the striatum, nucleus accumbens, and prefrontal cortex.
Gene_expression (expressed) of Nor-1 in nucleus accumbens associated with nucleus accumbens
3) Confidence 0.16 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0 Pain Relevance 0.20
Nur77 and Nor-1 are expressed in dopaminoceptive areas such as the striatum, nucleus accumbens, and prefrontal cortex.
Gene_expression (expressed) of Nor-1 in prefrontal associated with nucleus accumbens
4) Confidence 0.16 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0 Pain Relevance 0.20
Accordingly, the effects of haloperidol on striatal c-fos, Nor-1, and dynorphin mRNA expression are also preserved in NGFI-B-deficient mice.
Gene_expression (expression) of Nor-1 associated with dynorphin
5) Confidence 0.12 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.41 Pain Relevance 0.57
CD30 stimulation recently has been shown to cause eosinophil-specific apoptosis.142 It has been further reported that CD30 stimulation markedly induced Nur77 and NOR1, NR4A nuclear receptor family, during eosinophil-specific apoptosis.143 However, CD30 stimulation did not alter Nurr1 expression in this system.
Gene_expression (expression) of NOR1 in eosinophil associated with apoptosis
6) Confidence 0.05 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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