INT114272

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.82
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a1) DNA binding (Nr4a1)
Anatomy Link Frequency
nerve 4
striatum 2
eosinophil 2
Nr4a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 14 99.12 Very High Very High Very High
Nucleus accumbens 2 85.32 High High
antagonist 4 84.40 Quite High
Nerve growth factor 1 81.40 Quite High
midbrain 1 80.36 Quite High
Neuropeptide 11 75.20 Quite High
Enkephalin 7 69.52 Quite High
corticosteroid 5 53.20 Quite High
Substantia nigra 1 51.60 Quite High
Ventral tegmentum 1 49.92 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 77 100.00 Very High Very High Very High
Psychosis 1 87.44 High High
Disease 21 86.88 High High
Targeted Disruption 15 82.80 Quite High
Lymphatic System Cancer 2 78.12 Quite High
Catalepsy 4 77.04 Quite High
Diffuse Large B-cell Lymphoma 1 77.04 Quite High
INFLAMMATION 16 41.20 Quite Low
Asthma 24 39.28 Quite Low
Fibrosis 2 31.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that dopamine (DA) denervation and repeated L-DOPA treatment modulate the pattern of Nur77 mRNA expression in the striatum.
Regulation (modulate) of Gene_expression (expression) of Nur77 in striatum associated with dopamine
1) Confidence 0.45 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930409 Disease Relevance 0.16 Pain Relevance 0.24
We have previously shown that neuroleptics modulated the expression of some members of the ligand-activated transcription factors (nuclear receptors) including the nerve-growth factor inducible gene B (NGFI-B or Nur77) and retinoid X receptor (RXR) isoforms.
Regulation (modulated) of Gene_expression (expression) of NGFI-B in nerve
2) Confidence 0.45 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.36 Pain Relevance 0.28
We have previously shown that neuroleptics modulated the expression of some members of the ligand-activated transcription factors (nuclear receptors) including the nerve-growth factor inducible gene B (NGFI-B or Nur77) and retinoid X receptor (RXR) isoforms.
Regulation (modulated) of Gene_expression (expression) of Nur77 in nerve
3) Confidence 0.45 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.37 Pain Relevance 0.28
Modulation of Nur77 and Nor-1 mRNA expression by antipsychotics can be used to calculate an index that is predictive of the typical or atypical profile of antipsychotic drugs.
Regulation (Modulation) of Gene_expression (expression) of Nur77
4) Confidence 0.34 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.09 Pain Relevance 0.27
CD30 stimulation recently has been shown to cause eosinophil-specific apoptosis.142 It has been further reported that CD30 stimulation markedly induced Nur77 and NOR1, NR4A nuclear receptor family, during eosinophil-specific apoptosis.143 However, CD30 stimulation did not alter Nurr1 expression in this system.
Neg (not) Regulation (alter) of Gene_expression (expression) of Nur77 in eosinophil associated with apoptosis
5) Confidence 0.04 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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