INT114274

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 67
Total Number 67
Disease Relevance 36.77
Pain Relevance 12.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxra) enzyme binding (Rxra) DNA binding (Rxra)
transcription factor binding (Rxra)
Anatomy Link Frequency
hepatocyte 4
CAR 3
spinal cord 2
epithelial cells 2
nerve 2
Rxra (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 638 100.00 Very High Very High Very High
Inflammation 1341 99.98 Very High Very High Very High
Spinal cord 492 99.72 Very High Very High Very High
Peripheral nerve injury 30 99.72 Very High Very High Very High
Peripheral nervous system 91 99.28 Very High Very High Very High
cytokine 331 96.76 Very High Very High Very High
Central nervous system 256 96.16 Very High Very High Very High
cINOD 179 96.04 Very High Very High Very High
Arthritis 43 94.84 High High
Multiple sclerosis 2 93.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1733 99.98 Very High Very High Very High
Infertility 1 99.98 Very High Very High Very High
Rheumatoid Arthritis 878 99.92 Very High Very High Very High
Obesity 417 99.84 Very High Very High Very High
Frailty 300 99.72 Very High Very High Very High
Keloid Scars 16 99.56 Very High Very High Very High
Nervous System Injury 60 99.28 Very High Very High Very High
Injury 383 98.92 Very High Very High Very High
Lung Cancer 27 98.28 Very High Very High Very High
Osteogenic Sarcomas 86 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
express RXR?
Gene_expression (express) of RXR
1) Confidence 0.70 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.39 Pain Relevance 0.46
agonists of either RXR or PPAR, leading to the activation of
Gene_expression (agonists) of RXR associated with agonist
2) Confidence 0.61 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.29 Pain Relevance 0.30
exclusively in hepatocytes

[10], RXR?

Gene_expression (exclusively) of RXR in hepatocytes
3) Confidence 0.61 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.38 Pain Relevance 0.43
agonists of either RXR or PPAR, leading to the activation of
Gene_expression (either) of RXR associated with agonist
4) Confidence 0.61 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.29 Pain Relevance 0.30
The RXR/PPAR heterodimer is activated by
Gene_expression (heterodimer) of RXR
5) Confidence 0.61 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.30 Pain Relevance 0.30
PPARs in the absence of RXR?
Neg (absence) Gene_expression (absence) of RXR
6) Confidence 0.61 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.38 Pain Relevance 0.48
deleting hepatocyte-specific RXR?
Gene_expression (specific) of RXR in hepatocyte
7) Confidence 0.53 Published 2006 Journal PPAR Research Section Abstract Doc Link PMC1664714 Disease Relevance 0.37 Pain Relevance 0.32
that the hepatocyte-specific RXR?
Gene_expression (specific) of RXR in hepatocyte
8) Confidence 0.53 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.72 Pain Relevance 0.46
deleting hepatocyte-specific RXR?
Gene_expression (deleting) of RXR in hepatocyte
9) Confidence 0.53 Published 2006 Journal PPAR Research Section Abstract Doc Link PMC1664714 Disease Relevance 0.37 Pain Relevance 0.32
In addition, we demonstrate that haloperidol enhances colocalization of NGFI-B and RXRgamma1 isoform mRNAs, suggesting that both NGFI-B and a RXR isoform are highly coexpressed after haloperidol administration.
Gene_expression (coexpressed) of RXR isoform
10) Confidence 0.48 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.33 Pain Relevance 0.48
We have previously shown that neuroleptics modulated the expression of some members of the ligand-activated transcription factors (nuclear receptors) including the nerve-growth factor inducible gene B (NGFI-B or Nur77) and retinoid X receptor (RXR) isoforms.
Gene_expression (expression) of retinoid X receptor in nerve
11) Confidence 0.48 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.38 Pain Relevance 0.29
We have previously shown that neuroleptics modulated the expression of some members of the ligand-activated transcription factors (nuclear receptors) including the nerve-growth factor inducible gene B (NGFI-B or Nur77) and retinoid X receptor (RXR) isoforms.
Gene_expression (expression) of RXR in nerve
12) Confidence 0.48 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.38 Pain Relevance 0.29
There is evidence suggesting that the relative expression level of different NRs and RXR dictates the activity of individual NR pathways.
Gene_expression (expression) of RXR
13) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.12 Pain Relevance 0
sterility observed in RXR?
Gene_expression (observed) of RXR associated with infertility
14) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266973 Disease Relevance 0.16 Pain Relevance 0
The crystal structures of several RXR/partner LBD heterodimers have been resolved since the publication of the RXR LBD homodimer, including RXR/RAR [39, 40], RXR/CAR [41, 42], RXR/LXR [43, 44], and RXR/PPAR [25, 45–47].
Gene_expression (/) of RXR in CAR
15) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
Interestingly, RAR acquires the heterodimerization properties of RXR when its I-box is replaced by that of the RXR, and vice versa [57].
Gene_expression (acquires) of RXR
16) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
Our laboratory has created and tested an engineered RXR/PPAR heterodimer consist of mouse RXR?
Gene_expression (consist) of RXR
17) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.07 Pain Relevance 0
The creation of these mutants is based on the proposed salt-bridge between RXR?
Gene_expression (bridge) of RXR in bridge
18) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.06 Pain Relevance 0
The crystal structures of several RXR/partner LBD heterodimers have been resolved since the publication of the RXR LBD homodimer, including RXR/RAR [39, 40], RXR/CAR [41, 42], RXR/LXR [43, 44], and RXR/PPAR [25, 45–47].
Gene_expression (/) of RXR in CAR
19) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
This inhibition can be relieved by the addition of RXR?
Gene_expression (addition) of RXR
20) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

General Comments

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