INT114276

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 7.71
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a1) DNA binding (Nr4a1)
Anatomy Link Frequency
stroma 2
striatum 2
nerve 2
mammary gland 1
eosinophil 1
Nr4a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 5 99.22 Very High Very High Very High
Dopamine 29 99.16 Very High Very High Very High
midbrain 4 98.80 Very High Very High Very High
Nucleus accumbens 8 98.08 Very High Very High Very High
Enkephalin 15 95.92 Very High Very High Very High
agonist 6 94.64 High High
antagonist 8 89.88 High High
Hippocampus 75 87.64 High High
Nerve growth factor 1 81.40 Quite High
Neuropeptide 20 78.96 Quite High
Disease Link Frequency Relevance Heat
Convulsion 521 100.00 Very High Very High Very High
Apoptosis 143 100.00 Very High Very High Very High
Sprains And Strains 236 99.54 Very High Very High Very High
Body Weight 27 96.52 Very High Very High Very High
Breast Cancer 24 92.28 High High
Attention Deficit Hyperactivity Disorder 3 89.96 High High
Psychosis 4 87.44 High High
Catalepsy 8 87.32 High High
Disease 33 86.88 High High
Death 60 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that neuroleptics modulated the expression of some members of the ligand-activated transcription factors (nuclear receptors) including the nerve-growth factor inducible gene B (NGFI-B or Nur77) and retinoid X receptor (RXR) isoforms.
Gene_expression (expression) of Nur77 in nerve
1) Confidence 0.77 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.37 Pain Relevance 0.28
We have previously shown that neuroleptics modulated the expression of some members of the ligand-activated transcription factors (nuclear receptors) including the nerve-growth factor inducible gene B (NGFI-B or Nur77) and retinoid X receptor (RXR) isoforms.
Gene_expression (expression) of NGFI-B in nerve
2) Confidence 0.77 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.36 Pain Relevance 0.28
In addition, we demonstrate that haloperidol enhances colocalization of NGFI-B and RXRgamma1 isoform mRNAs, suggesting that both NGFI-B and a RXR isoform are highly coexpressed after haloperidol administration.
Gene_expression (coexpressed) of NGFI-B
3) Confidence 0.77 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.33 Pain Relevance 0.48
We have previously shown that dopamine (DA) denervation and repeated L-DOPA treatment modulate the pattern of Nur77 mRNA expression in the striatum.
Gene_expression (expression) of Nur77 in striatum associated with dopamine
4) Confidence 0.67 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930409 Disease Relevance 0.16 Pain Relevance 0.24
Nur77 and Nor-1 are expressed in dopaminoceptive areas such as the striatum, nucleus accumbens, and prefrontal cortex.
Gene_expression (expressed) of Nur77 in striatum associated with nucleus accumbens
5) Confidence 0.66 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0 Pain Relevance 0.20
In addition, the behavioral phase shifts are highly correlated with changes in Fos expression, but not with Egr1 or Nr4a1 expression [38].
Gene_expression (expression) of Nr4a1
6) Confidence 0.62 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.06 Pain Relevance 0
Accordingly, the effects of haloperidol on striatal c-fos, Nor-1, and dynorphin mRNA expression are also preserved in NGFI-B-deficient mice.
Gene_expression (deficient) of NGFI-B associated with dynorphin
7) Confidence 0.59 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.40 Pain Relevance 0.56
Modulation of Nur77 and Nor-1 mRNA expression by antipsychotics can be used to calculate an index that is predictive of the typical or atypical profile of antipsychotic drugs.
Gene_expression (expression) of Nur77
8) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.09 Pain Relevance 0.27
On average, when the C57BL/6 alleles were present, Fos, Nr4a1, and Id2 expressed higher levels than when the DBA/2J alleles were present.
Gene_expression (expressed) of Nr4a1
9) Confidence 0.50 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.47 Pain Relevance 0
Accordingly, the different expression levels of Nur77 in various cell types might explain the opposite effects of Bcl-2 on Apoptin induced apoptosis.
Gene_expression (expression) of Nur77 associated with apoptosis
10) Confidence 0.23 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 0.92 Pain Relevance 0
Nur77 and Nor-1 are expressed in dopaminoceptive areas such as the striatum, nucleus accumbens, and prefrontal cortex.
Gene_expression (expressed) of Nur77 in prefrontal associated with nucleus accumbens
11) Confidence 0.22 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0 Pain Relevance 0.20
Nur77 and Nor-1 are expressed in dopaminoceptive areas such as the striatum, nucleus accumbens, and prefrontal cortex.
Gene_expression (expressed) of Nur77 in nucleus accumbens associated with nucleus accumbens
12) Confidence 0.22 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0 Pain Relevance 0.20
Since expression patterns of these transcripts correlated to the chromosome 12 locus, it follows that their expression patterns are correlated to each other: Fos, Nr4a1, and Id2 were positively co-regulated by C57BL/6 alleles and were also positively correlated with each other (r > 0.68), whereas they were negatively correlated with Gfap (r < ?
Gene_expression (expression) of Nr4a1
13) Confidence 0.22 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.43 Pain Relevance 0
Because it has been shown that the stroma may be a target in radiation-induced [64] and in chemical-induced carcinogenesis [65], other players important in parenchymal-stromal interactions related with hormone receptor expression may be involved in all models.


Gene_expression (expression) of hormone receptor in stroma
14) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.51 Pain Relevance 0
In contrast, following bupropion HBr 100 mg/kg treatment, only five rats (50%) were observed to have convulsions that were also expressed as facial clonus with or without forelimb clonus and rearing (except one rat that had a fatal whole body clonus).
Gene_expression (expressed) of HBr in body associated with convulsion
15) Confidence 0.09 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695230 Disease Relevance 0.67 Pain Relevance 0.09
Immunostaining for neuron-specific antigen (NeuN immunostaining) of sections from the HCl/HBr treated mice confirmed the normal appearance of morphology within neuronal populations in each brain region examined.
Gene_expression (immunostaining) of HBr in neuronal
16) Confidence 0.09 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695230 Disease Relevance 0.56 Pain Relevance 0.17
CD30 stimulation recently has been shown to cause eosinophil-specific apoptosis.142 It has been further reported that CD30 stimulation markedly induced Nur77 and NOR1, NR4A nuclear receptor family, during eosinophil-specific apoptosis.143 However, CD30 stimulation did not alter Nurr1 expression in this system.
Gene_expression (expression) of Nur77 in eosinophil associated with apoptosis
17) Confidence 0.09 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.84 Pain Relevance 0.07
Although we cannot at this time rule out the participation of other, untested factors, our findings implicate the stroma as playing a crucial role in the strain-specific differential hormone receptor expression and hormone responsiveness.



Gene_expression (expression) of hormone receptor in stroma associated with sprains and strains
18) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC1868922 Disease Relevance 0.54 Pain Relevance 0
These results indicate that host factors are responsible for the strain differences observed in mammary gland hormone receptor expression and that the level of these receptors is related to the degree of hormone responsiveness.



Gene_expression (expression) of hormone receptor in mammary gland associated with sprains and strains
19) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.71 Pain Relevance 0
The doses of bupropion HCl are expressed in mg/kg of salt and the doses of bupropion HBr are expressed in mg/kg bupropion HCl molar equivalent (correction factor = 1.16).


Gene_expression (expressed) of HBr in molar
20) Confidence 0.08 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695230 Disease Relevance 0.29 Pain Relevance 0.10

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