INT114279

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.37
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a1) DNA binding (Nr4a1)
Anatomy Link Frequency
brain 2
substantia nigra 1
nerve 1
eosinophil 1
ventral 1
Nr4a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 6 100.00 Very High Very High Very High
Nerve growth factor 2 100.00 Very High Very High Very High
Substantia nigra 7 98.08 Very High Very High Very High
Ventral tegmentum 3 97.24 Very High Very High Very High
Nucleus accumbens 6 89.68 High High
Dynorphin 1 87.68 High High
Dopamine 12 86.28 High High
agonist 3 83.88 Quite High
midbrain 3 81.36 Quite High
Calcium channel 1 79.16 Quite High
Disease Link Frequency Relevance Heat
Convulsion 173 100.00 Very High Very High Very High
Apoptosis 88 98.70 Very High Very High Very High
Brain Injury 4 97.20 Very High Very High Very High
Psychosis 3 84.88 Quite High
Disorders Of The Lacrimal System 85 84.48 Quite High
Dry Eye 4 81.48 Quite High
Lymphatic System Cancer 2 78.44 Quite High
Diffuse Large B-cell Lymphoma 1 77.36 Quite High
Catalepsy 2 76.56 Quite High
Colon Cancer 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to classical gene patterns induced in the striatal complex (striatum, accumbens) and cortex, most antipsychotic drugs tested strongly induced Nur77, Nor-1, and increased Nurr1 mRNA levels in the substantia nigra and ventral tegmental area.
Positive_regulation (induced) of Nur77 in substantia nigra associated with ventral tegmentum and substantia nigra
1) Confidence 0.59 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.08 Pain Relevance 0.30
In addition, we demonstrate that haloperidol enhances colocalization of NGFI-B and RXRgamma1 isoform mRNAs, suggesting that both NGFI-B and a RXR isoform are highly coexpressed after haloperidol administration.
Positive_regulation (enhances) of NGFI-B
2) Confidence 0.22 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603264 Disease Relevance 0.34 Pain Relevance 0.50
1,1-Bis(3'-indolyl)-1-(p-methoxyphenyl)methane (DIM-C-pPhOCH(3)) is a methylene-substituted diindolylmethane (C-DIM) analog that activates the orphan receptor nerve growth factor-induced-Balpha (NGFI-Balpha, Nur77).
Positive_regulation (activates) of Nur77 in nerve associated with nerve growth factor
3) Confidence 0.21 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 17957723 Disease Relevance 0.31 Pain Relevance 0.05
In addition to classical gene patterns induced in the striatal complex (striatum, accumbens) and cortex, most antipsychotic drugs tested strongly induced Nur77, Nor-1, and increased Nurr1 mRNA levels in the substantia nigra and ventral tegmental area.
Positive_regulation (induced) of Nur77 in ventral associated with ventral tegmentum and substantia nigra
4) Confidence 0.20 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15615863 Disease Relevance 0.08 Pain Relevance 0.30
The remaining five genes are well known light-induced genes: Egr1, Egr3, Fos, Nr4a1, and Jun.
Positive_regulation (light-induced) of Nr4a1
5) Confidence 0.18 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.17 Pain Relevance 0.04
Induction patterns of transcription factors of the nur family (nurr1, nur77, and nor-1) by typical and atypical antipsychotics in the mouse brain: implication for their mechanism of action.
Positive_regulation (Induction) of nur77 in brain associated with enkephalin
6) Confidence 0.17 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15615863 Disease Relevance 0.05 Pain Relevance 0.29
After androgen binding to the receptor, the monomeric, activated hormone-receptor complex associates with an androgen response element in the regulatory region of specific target genes, typically dimerizes with another androgen-bound complex and, in combination with appropriate coactivators and promoter elements, modulates gene transcription [55,56]. 
Positive_regulation (activated) of hormone-receptor
7) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2728565 Disease Relevance 0.85 Pain Relevance 0.03
The results in mice showed that bupropion HCl 125 mg/kg induced a significantly higher ten-fold increase in the mean number of cortical EEG seizures compared to bupropion HBr (7.50 ± 2.56 vs 0.75 ± 0.96; p = 0.045), but neither drug caused any brain injuries.
Positive_regulation (induced) of HBr in brain associated with convulsion and brain injury
8) Confidence 0.07 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2695230 Disease Relevance 0.73 Pain Relevance 0.04
CD30 stimulation recently has been shown to cause eosinophil-specific apoptosis.142 It has been further reported that CD30 stimulation markedly induced Nur77 and NOR1, NR4A nuclear receptor family, during eosinophil-specific apoptosis.143 However, CD30 stimulation did not alter Nurr1 expression in this system.
Positive_regulation (induced) of Nur77 in eosinophil associated with apoptosis
9) Confidence 0.07 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.74 Pain Relevance 0.04

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