INT11429

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Context Info
Confidence 0.74
First Reported 1988
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 5.89
Pain Relevance 11.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
Anatomy Link Frequency
embryonic kidney 2
SK-N-SH 2
plasma 1
SH-SY5Y 1
CSF 1
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 112 100.00 Very High Very High Very High
Immobilon 21 100.00 Very High Very High Very High
5HT 2 100.00 Very High Very High Very High
Delta opioid receptors 2 100.00 Very High Very High Very High
Calcitonin gene-related peptide 13 99.52 Very High Very High Very High
Neuropeptide 8 99.52 Very High Very High Very High
Buprenorphine 10 99.46 Very High Very High Very High
Opioid 61 99.32 Very High Very High Very High
Codeine 7 99.20 Very High Very High Very High
Morphine 79 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 13 99.68 Very High Very High Very High
Neuroblastoma 15 99.62 Very High Very High Very High
Schizophrenia 81 99.20 Very High Very High Very High
Urological Neuroanatomy 11 98.80 Very High Very High Very High
Psychosis 171 98.48 Very High Very High Very High
Adhesions 1 97.60 Very High Very High Very High
Ganglion Cysts 8 97.40 Very High Very High Very High
Manic Depressive Disorder 42 94.96 High High
Congenital Anomalies 11 92.92 High High
Injury 17 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken collectively, these data suggest that SH-SY5Y cells express type 1, and possibly type 8 isoforms of adenylyl cyclase, which can be regulated by intra- and extracellular Ca2+.
Gene_expression (express) of adenylyl cyclase in SH-SY5Y
1) Confidence 0.74 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7786304 Disease Relevance 0.07 Pain Relevance 0.33
We also expressed the adenylyl cyclases in cells that were transfected with D1A receptor and G beta 1 and G gamma 2 cDNAs.
Gene_expression (expressed) of adenylyl cyclase
2) Confidence 0.65 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700117 Disease Relevance 0.09 Pain Relevance 0.90
The expression of multiple adenylyl cyclase proteins was confirmed by immunochemistry with subtype-specific antibodies.
Gene_expression (expression) of cyclase
3) Confidence 0.62 Published 2001 Journal Reproduction Section Abstract Doc Link 11226046 Disease Relevance 0 Pain Relevance 0.04
Buprenorphine prevents and reverses the expression of chronic etorphine-induced sensitization of adenylyl cyclase in SK-N-SH human neuroblastoma cells.
Gene_expression (expression) of cyclase in SK-N-SH associated with neuroblastoma, immobilon and buprenorphine
4) Confidence 0.56 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8380866 Disease Relevance 0.26 Pain Relevance 1.40
The strong stimulation by forskolin indicates that adenylyl cyclase IX is unlikely to be the major source of cyclase activity in these cells.
Gene_expression (source) of cyclase
5) Confidence 0.55 Published 2001 Journal Reproduction Section Abstract Doc Link 11226046 Disease Relevance 0 Pain Relevance 0.17
The strong stimulation by forskolin indicates that adenylyl cyclase IX is unlikely to be the major source of cyclase activity in these cells.
Gene_expression (source) of cyclase
6) Confidence 0.48 Published 2001 Journal Reproduction Section Abstract Doc Link 11226046 Disease Relevance 0 Pain Relevance 0.17
Preincubation of the cells with carbachol for 30 min resulted in a significant increase in prostaglandin E1-stimulated cAMP accumulation in cells expressing type VI, but not type I or type II, adenylyl cyclase.
Neg (not) Gene_expression (expressing) of cyclase
7) Confidence 0.46 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8622641 Disease Relevance 0 Pain Relevance 0.24
-adrenergic receptors and adenyl cyclase resulting in activation of cyclic AMP (cAMP), causing subsequent increases in circulating epinephrine [30,31] and free fatty acids [32].
Gene_expression (resulting) of adenyl cyclase
8) Confidence 0.39 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2276475 Disease Relevance 0 Pain Relevance 0
The pharmacologic profile of S12 as seen in adenylyl cyclase assays is as follows: (EC50 in nM): serotonin, full agonist (37 nM), 5-carboxamidotryptamine, full agonist (10 nM), sumatriptan, full agonist (50 nM), metergoline, partial agonist (10 nM), methysergide, partial agonist (40 nM), yohimbine, partial agonist (150 nM), metitepin, antagonist (KB = 0.7 to 1.2 nM).
Gene_expression (assays) of adenylyl cyclase associated with sumatriptan, antagonist, agonist and serotonin
9) Confidence 0.39 Published 1992 Journal J. Biol. Chem. Section Abstract Doc Link 1559993 Disease Relevance 0 Pain Relevance 0.62
Co-expression of the mu-opioid receptor with type II adenylyl cyclase in human embryonic kidney 293 cells allowed the mu-selective agonist, [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin, to stimulate cyclic AMP accumulation in a dose-dependent manner.
Gene_expression (expression) of cyclase in embryonic kidney associated with agonist, enkephalin and opioid receptor
10) Confidence 0.34 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595566 Disease Relevance 0.14 Pain Relevance 0.55
The results suggest that CGRP-1 receptors coupled to adenylyl cyclase are present in human cerebral arteries.
Gene_expression (present) of adenylyl cyclase associated with calcitonin gene-related peptide
11) Confidence 0.26 Published 1996 Journal Cephalalgia Section Abstract Doc Link 8869765 Disease Relevance 0.07 Pain Relevance 0.72
Co-transfection of the delta-opioid receptor with type II adenylyl cyclase and an activated mutant of alpha s converted the delta-opioid signal from inhibition to stimulation of cAMP accumulation.
Gene_expression (Co-transfection) of adenylyl cyclase associated with opioid receptor and opioid
12) Confidence 0.26 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7760050 Disease Relevance 0.17 Pain Relevance 0.95
Lidocaine (0.1 mmol/l) and codeine (1.0 mmol/l) similarly potentiated the effect of the adenylate cyclase stimulator prostaglandin E1 (PGE1).
Gene_expression (effect) of adenylate cyclase stimulator prostaglandin E1 associated with lidocaine and codeine
13) Confidence 0.25 Published 1988 Journal Arzneimittelforschung Section Abstract Doc Link 2840087 Disease Relevance 0 Pain Relevance 0.68
In SK-N-SH human neuroblastoma cells, morphine significantly increased RNA transcript and protein levels of type I adenylate cyclase, leading to sensitization.
Gene_expression (levels) of type I adenylate cyclase in SK-N-SH associated with neuroblastoma and morphine
14) Confidence 0.23 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20100459 Disease Relevance 0.35 Pain Relevance 0.54
Wild-type or mutant alpha(z) was transiently coexpressed with different receptors and adenylyl cyclase isozymes in human embryonic kidney 293 cells, and agonist-dependent regulation of cyclic AMP accumulation was examined in a setting where all endogenous alpha subunits of G1 were inactivated by pertussis toxin.
Gene_expression (coexpressed) of adenylyl cyclase in embryonic kidney associated with bordatella infection and agonist
15) Confidence 0.22 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9166747 Disease Relevance 0.09 Pain Relevance 0.24
These data indicate that the expression of alpha-transducin scavenges free G(beta gamma) subunits and, furthermore, that free G(beta gamma) subunits play a role in opioid-mediated PLC beta activation and adenylyl cyclase superactivation, but not acute inhibition of forskolin-stimulated cAMP formation in hDOR/CHO cells.
Gene_expression (superactivation) of adenylyl cyclase in CHO associated with opioid
16) Confidence 0.19 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641436 Disease Relevance 0.07 Pain Relevance 0.25
The human neuroblastoma cell line SK-N-BE expresses delta-opioid receptors negatively coupled to adenylyl cyclase.
Gene_expression (expresses) of adenylyl cyclase associated with neuroblastoma and delta opioid receptors
17) Confidence 0.18 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084451 Disease Relevance 0.17 Pain Relevance 0.16
Thus, sustained activation of the MOP receptor by morphine in sc2 cells seems to promote proteasomal degradation of Gbeta to sensitize adenylate cyclase.
Gene_expression (sensitize) of cyclase associated with opioid and morphine
18) Confidence 0.07 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15901846 Disease Relevance 0.19 Pain Relevance 0.86
Presence of pituitary adenylate cyclase activating polypeptide-38 in human plasma and milk.
Gene_expression (Presence) of cyclase in plasma
19) Confidence 0.06 Published 2009 Journal Eur. J. Endocrinol. Section Title Doc Link 19174531 Disease Relevance 0.17 Pain Relevance 0.17
Whole cell adenylyl cyclase assays
Gene_expression (assays) of adenylyl cyclase
20) Confidence 0.04 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC137588 Disease Relevance 0 Pain Relevance 0.08

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