INT114295

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.58
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gli2) anatomical structure formation involved in morphogenesis (Gli2) intracellular (Gli2)
cilium (Gli2) DNA binding (Gli2) cytoplasm (Gli2)
Anatomy Link Frequency
T cells 2
articular 1
lung 1
ventral 1
Gli2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 64 100.00 Very High Very High Very High
Inflammation 184 98.18 Very High Very High Very High
Endocannabinoid 16 97.28 Very High Very High Very High
ischemia 26 96.32 Very High Very High Very High
Snapping jaw 7 94.84 High High
Multiple sclerosis 52 94.80 High High
Central nervous system 10 91.08 High High
cINOD 13 82.64 Quite High
Potency 17 78.76 Quite High
Cannabinoid 34 74.96 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 20 99.48 Very High Very High Very High
Chondroma 41 99.02 Very High Very High Very High
Rhinitis 5 98.32 Very High Very High Very High
INFLAMMATION 186 98.18 Very High Very High Very High
Eczema 28 96.52 Very High Very High Very High
Cv Unclassified Under Development 27 96.32 Very High Very High Very High
Enchondromatosis 56 94.88 High High
Injury 170 94.84 High High
Temporomandibular Joint Syndrome 7 94.84 High High
Multiple Sclerosis 64 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In wild-type mouse embryos, Ihh expression was already strong in condylar cartilage by embryonic day (E) 15.5, and expression of Ihh receptors and effector genes (Gli1, Gli2, Gli3, and PTHrP) indicated that Ihh range of action normally reached apical condylar tissue layers, including polymorphic chondroprogenitor layer and articular disc primordia.
Gene_expression (expression) of Gli2 in articular
1) Confidence 0.54 Published 2007 Journal Dev. Dyn. Section Abstract Doc Link 17191253 Disease Relevance 0.43 Pain Relevance 0.43
Because regulation of Ihh by PTHrP was found to be lost in these enchondromas, additional transgenic mice were generated that overexpress the Hedgehog (Hh) transcriptional regulator, Gli2.
Gene_expression (overexpress) of Gli2 associated with targeted disruption and chondroma
2) Confidence 0.32 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1592482 Disease Relevance 1.51 Pain Relevance 0
Notably absent from the list of repressed targets are SSTFs that are known to be expressed specifically in nascent postmitotic ventral interneurons (Evx1, Evx2, En1, Chx10, Sim1, Sox14, Etv1, Etv4, Gata2, Gata3), motor neurons (Isl2, Lhx3, Lhx4, Hlxb9 (Hb9, MNR2)), or the ventral progenitor laminae (Dbx1, Dbx2, Nkx6.2, Nkx6.1, Irx3, Olig1, Olig2, Nkx2.2, Nkx2.9, Pax6, Gli1, Gli2, Gli3).
Gene_expression (expressed) of Gli2 in ventral
3) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
Inhalation of APC significantly inhibited the expression of T helper 2 (Th2) cytokines, immunoglobulin E (IgE), eosinophilic inflammation, and hyperresponsiveness.
Gene_expression (expression) of helper 2 associated with rhinitis, inflammation and cytokine
4) Confidence 0.02 Published 2004 Journal Blood Section Abstract Doc Link 14604971 Disease Relevance 0.99 Pain Relevance 0.44
In contrast, mite allergen treatment induced the expression of T helper 2 (TH2)-type cytokines, including IL-4, IL-5, IL-13, and RANTES, compared with no treatment or saline treatment, whereas maternal exposure to DEHP during neonatal periods did not significantly enhance the effects (data not shown).
Gene_expression (expression) of helper 2 associated with cytokine
5) Confidence 0.02 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535612 Disease Relevance 0.46 Pain Relevance 0.05
The time course of ovalbumin-induced production of the bronchoalveolar lavage T-helper 2 cytokines (interleukin-5 and interleukin-4) was also studied.
Gene_expression (production) of T-helper 2 associated with cytokine
6) Confidence 0.02 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.58 Pain Relevance 0.29
However, in our study, gender did not affect T-helper 2 cytokine production which is in contradiction to previously published results.
Gene_expression (production) of T-helper 2 associated with cytokine
7) Confidence 0.02 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.65 Pain Relevance 0.40
In addition, in vitro restimulation of lung homogenates with ovalbumin induced an increased production of T-helper 2 cytokines in female versus male mice.
Gene_expression (production) of T-helper 2 in lung associated with cytokine
8) Confidence 0.02 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406499 Disease Relevance 0.54 Pain Relevance 0.35
Furthermore, evidence suggests that endocannabinoids have immunosuppressant and anti-inflammatory properties, they downregulate the production of T helper 1 (Th1) cytokines, enhancing the production of T helper 2 (Th2) cytokines, since a polarization of T cell response towards a Th2 phenotype has been associated with therapeutic benefit in MS, while a shift towards Th1 has been associated with disease progression (Matsuda et al 1990; Hemmer 2002).
Gene_expression (production) of helper 2 in T cell associated with endocannabinoid, multiple sclerosis, inflammation, disease progression and cytokine
9) Confidence 0.02 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 0.83 Pain Relevance 0.82
CD4 T cells can functionally differentiate into either a T helper 1 (IFN-gamma producing) or the counterbalancing T helper 2 (IL-4 producing) phenotype.
Gene_expression (producing) of helper 2 in T cells
10) Confidence 0.01 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.59 Pain Relevance 0.17

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