INT114298

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.79
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) aging (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Anatomy Link Frequency
fibroblasts 2
smooth muscle cells 2
Ednrb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 10 99.84 Very High Very High Very High
Morphine 10 94.80 High High
Kinase C 25 88.40 High High
agonist 2 87.76 High High
antagonist 18 85.44 High High
ischemia 10 66.40 Quite High
metalloproteinase 1 51.56 Quite High
fibrosis 4 34.92 Quite Low
cva 5 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 71 99.84 Very High Very High Very High
Middle Cerebral Artery Infarction 15 97.56 Very High Very High Very High
Pulmonary Disease 1 96.68 Very High Very High Very High
Systemic Sclerosis 6 96.42 Very High Very High Very High
Disease 20 95.88 Very High Very High Very High
Cv General 4 Under Development 14 67.12 Quite High
Fibrosis 5 36.76 Quite Low
Weight Loss 1 35.28 Quite Low
Hypoxia 4 30.80 Quite Low
Hypertrophy 3 10.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the control group, immunohistochemistry confirmed an enhanced expression of ETB receptor protein in the smooth muscle cells of the right MCA after transient MCAO.
Positive_regulation (enhanced) of Gene_expression (expression) of ETB receptor protein in smooth muscle cells associated with middle cerebral artery infarction
1) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.22 Pain Relevance 0.25
In vitro data with skin fibroblasts suggested that targeting both the ETA and the ETB receptors is preferable in order to block collagen type I and III production.54 However, subsequent in vitro data using lung fibroblasts indicate that ET-1 induces collagen matrix contraction through the ETA receptor, but not the ETB receptor.55 Furthermore, while there is evidence that ETB receptors are linked to collagen production in vitro, in vivo animal data with ETA antagonists have shown that they effectively block the accumulation of collagen I, III, and IV,56 normalize pro-collagen I and III mRNA,49 and abolish the effect of ET-1 on pro-collagen metabolism.57 Likewise, although there is evidence that under certain conditions ET-1 can act as a mitogen in vitro through both ETA- and ETB-receptor activation,58 ETB receptors have been shown to inhibit vascular SMC proliferation in vivo.59 It has been suggested that ETB receptors may be up-regulated on SMCs and fibroblasts in certain disease states such as scleroderma lung disease.60 However, the spatial distribution of these receptors among different cell types within the lung microcirculation remains unclear, as does the significance of any increased ETB-receptor expression in PAH.


Positive_regulation (increased) of Gene_expression (expression) of ETB-receptor in fibroblasts associated with pulmonary hypertension, pulmonary disease, antagonist, systemic sclerosis and disease
2) Confidence 0.09 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.57 Pain Relevance 0.07
Naloxone caused a progressive decrease in ETA receptor mRNA expression at 6 h through 96 h and a 2-fold increase in ETB receptor mRNA expression at 48 and 96 h.
Positive_regulation (increase) of Gene_expression (expression) of ETB receptor mRNA associated with narcan
3) Confidence 0.02 Published 2004 Journal Pediatr. Res. Section Abstract Doc Link 14605251 Disease Relevance 0 Pain Relevance 0.54
Whereas ETA receptor mRNA expression increased 2-fold at 6 h and 4-fold at 96 h, ETB receptor mRNA expression remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of ETB receptor mRNA
4) Confidence 0.01 Published 2004 Journal Pediatr. Res. Section Abstract Doc Link 14605251 Disease Relevance 0 Pain Relevance 0.56

General Comments

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