INT114311

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 17.83
Pain Relevance 4.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
liver 16
plasma 4
hepatocytes 2
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 51 100.00 Very High Very High Very High
Nicotine 80 99.70 Very High Very High Very High
agonist 56 97.44 Very High Very High Very High
Inflammation 183 90.28 High High
Bile 14 88.96 High High
alcohol 14 85.52 High High
ischemia 57 84.36 Quite High
cytokine 127 81.12 Quite High
imagery 21 79.84 Quite High
Inflammatory response 20 76.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 129 100.00 Very High Very High Very High
Necrosis 73 100.00 Very High Very High Very High
Hepatotoxicity 85 99.92 Very High Very High Very High
Hepatitis B Virus Infection 81 99.62 Very High Very High Very High
Hepatitis 94 99.48 Very High Very High Very High
Viremia 1 99.40 Very High Very High Very High
Hepatitis C Virus Infection 200 99.24 Very High Very High Very High
Shock 158 99.24 Very High Very High Very High
Injury 396 98.74 Very High Very High Very High
Drug-induced Liver Injury 31 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum level of alanine transaminase (ALT) analysis
Negative_regulation (level) of Gene_expression (analysis) of ALT
1) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386525 Disease Relevance 0 Pain Relevance 0
Expectedly, MCS treatment significantly reduced ALT level after LPS injection.
Negative_regulation (reduced) of Gene_expression (level) of ALT
2) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386525 Disease Relevance 1.01 Pain Relevance 0.07
A similar pattern was observed in the pre-treated group 4 h after the administration of paracetamol with a reduction in serum levels of ALT, aspartate aminotransferase and alkaline phosphatase enzymes by 65.04, 55.79 and 45.75% respectively (P < 0.001).
Negative_regulation (reduction) of Gene_expression (levels) of ALT associated with paracetamol
3) Confidence 0.35 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 14607024 Disease Relevance 0.22 Pain Relevance 0.38
WLP-S-10 200 mg/kg markedly reduced liver necrosis, serum ALT and AST elevation and GSH depletion after injection of acetaminophen.
Negative_regulation (depletion) of Gene_expression (elevation) of serum ALT in liver
4) Confidence 0.35 Published 2008 Journal Liver Int. Section Body Doc Link 18435715 Disease Relevance 0.05 Pain Relevance 0
WLP-S-10 200 mg/kg markedly reduced liver necrosis, serum ALT and AST elevation and GSH depletion after injection of acetaminophen.
Negative_regulation (reduced) of Gene_expression (elevation) of serum ALT in liver
5) Confidence 0.35 Published 2008 Journal Liver Int. Section Body Doc Link 18435715 Disease Relevance 0.05 Pain Relevance 0
DMPP treatment resulted in a 34% decrease in plasma ALT levels, while nicotine had no effect (Figure 2).
Negative_regulation (decrease) of Gene_expression (levels) of ALT in plasma associated with nicotine
6) Confidence 0.31 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.60 Pain Relevance 0.35
Preischemic treatment of mice with DMPP or nicotine significantly reduced ALT levels after 3 h of reperfusion compared to saline-treated mice (i.e., 65% inhibition for DMPP, and 69% for nicotine) (Figure 2).
Negative_regulation (reduced) of Gene_expression (levels) of ALT associated with nicotine
7) Confidence 0.31 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.71 Pain Relevance 0.35
Mice were sacrificed 12 h after the APAP injection to determine aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation, and caspase-3 expression in liver tissues.
Spec (determine) Negative_regulation (determine) of Gene_expression (levels) of ALT in liver associated with necrosis, paracetamol and cancer
8) Confidence 0.29 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.65 Pain Relevance 0.85
SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.
Negative_regulation (blocked) of Gene_expression (depletion) of ALT associated with paracetamol and hepatotoxicity
9) Confidence 0.29 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.67 Pain Relevance 0.99
Although there was no statistically significant difference in ALT levels between the wild-type and P/I null mice at either time point of reperfusion (i.e. 6 and 15 h), P/I null mice showed decreased ALT levels compared to the wild-type mice.


Negative_regulation (decreased) of Gene_expression (levels) of ALT
10) Confidence 0.28 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1891280 Disease Relevance 0.63 Pain Relevance 0.07
Prior to AAP treatment, the mice pretreated with FSSC showed significantly reduced levels of alanine aminotransferase (ALT) and aspirate aminotransferase (AST) activity.
Negative_regulation (reduced) of Gene_expression (levels) of ALT associated with paracetamol
11) Confidence 0.26 Published 2008 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 18838823 Disease Relevance 0.31 Pain Relevance 0.64
0.05, Figure 2A) and a 14-fold decrease in serum ALT levels (P?
Negative_regulation (decrease) of Gene_expression (levels) of serum ALT
12) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.36 Pain Relevance 0.26
After 24 h, Marimastat pre-treatment attenuated necroinflammatory hepatic injury as determined by histology (Figure 7A), and resulted in a 57% reduction in serum ALT levels (P?
Negative_regulation (reduction) of Gene_expression (levels) of serum ALT associated with injury
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.12 Pain Relevance 0.23
HS did not induce overt liver damage as measured by ALT levels; minor increases were observed by HS+WY treatment in wild-type but not PPAR?
Negative_regulation (measured) of Gene_expression (levels) of ALT in liver associated with shock and hepatotoxicity
14) Confidence 0.16 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 1.11 Pain Relevance 0.04
Interestingly, the decrease in severity of hepatitis (an approximately 8-fold decrease in AST and ALT levels) appeared greater than the decrease in NKT density or visitation rate (3-fold).
Negative_regulation (decrease) of Gene_expression (levels) of ALT associated with hepatitis
15) Confidence 0.15 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.50 Pain Relevance 0.04
As shown in Figure 6A, serum AST and ALT levels were markedly reduced at 12 h in cxcr6gfp/gfp mice as compared with cxcr6gfp/+ and cxcr6+/+ littermates.
Negative_regulation (reduced) of Gene_expression (levels) of ALT
16) Confidence 0.15 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.43 Pain Relevance 0
Levels of AST, ALT, ALKP, BRN, and tissue TBARS concentration increased by TAA treatment were decreased significantly (P < 0.01) by post-treatment of animals with OA (2 g/kg, p.o.) for 10 days.
Negative_regulation (decreased) of Gene_expression (Levels) of ALT
17) Confidence 0.10 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991698 Disease Relevance 0 Pain Relevance 0.06
TAA is known to cause changes in cell permeability by its metabolite thioacetamide-S-oxide.[23] In our study, the rise in AST, ALT, and ALKP levels induced by TAA administration was significantly reduced by OA post-treatment, suggesting that its protective activity might be due its effect against cellular leakage and loss of functional integrity of the cell membrane in hepatocytes.
Negative_regulation (reduced) of Gene_expression (levels) of ALT in hepatocytes
18) Confidence 0.10 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991698 Disease Relevance 0.39 Pain Relevance 0
The most interesting clinical observation is that ribavirin monotherapy had a minimal effect on HCV viremia, despite the fact that serum ALT levels were reduced significantly in a considerable proportion of patients with chronic HCV infection [18].
Negative_regulation (reduced) of Gene_expression (levels) of ALT associated with viremia, hepatitis c virus infection and infection
19) Confidence 0.08 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC2990099 Disease Relevance 0.75 Pain Relevance 0
The levels of ALT decreased significantly from week 4 to week 8 and in the subgroup analysis this significance was also seen in the female subjects.
Negative_regulation (decreased) of Gene_expression (levels) of ALT
20) Confidence 0.04 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0 Pain Relevance 0.08

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