INT114317

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Context Info
Confidence 0.54
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.40
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6r) extracellular region (Il6r) enzyme binding (Il6r)
Anatomy Link Frequency
neurons 2
liver 1
arcuate nucleus 1
knee joint 1
spinal cord 1
Il6r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 33 94.96 High High
cytokine 21 93.32 High High
Spinal cord 2 92.80 High High
Neuropathic pain 2 92.04 High High
rheumatoid arthritis 1 91.60 High High
agonist 4 81.76 Quite High
Inflammation 38 80.40 Quite High
allodynia 4 79.60 Quite High
antagonist 2 77.36 Quite High
Arthritis 52 73.72 Quite High
Disease Link Frequency Relevance Heat
Pain 28 94.96 High High
Neuropathic Pain 8 92.04 High High
Rheumatoid Arthritis 1 91.60 High High
Appetite Loss 42 89.52 High High
Death 4 88.16 High High
INFLAMMATION 34 80.40 Quite High
Necrosis 5 76.56 Quite High
Cancer 5 76.20 Quite High
Injury 2 74.00 Quite High
Arthritis 60 73.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following 50 mg/kg MPL treatment, expression of IL-6R1 mRNA exhibits a similar pattern as tyrosine aminotransferase (TAT) in the liver (Sun et al. 1998; Jin et al. 2003).
Gene_expression (expression) of IL-6R1 in liver
1) Confidence 0.54 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.05
TNF induced an increase of IL-6 receptor (IL-6R) expression in PC12 cells at 4-6 hr.
Gene_expression (expression) of IL-6R
2) Confidence 0.44 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607246 Disease Relevance 0.86 Pain Relevance 0.49
These data suggested that 6 hr pretreatment with TNF increased IL-6R expression in PC12 cells, leading to an enhancement of IL-6-induced neuroprotective action.To elucidate the role of p38 in pathological pain, we investigated whether p38 is activated in the spinal cord of the neuropathic pain model.
Gene_expression (expression) of IL-6R in spinal cord associated with pain, neuropathic pain and spinal cord
3) Confidence 0.44 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607246 Disease Relevance 0.91 Pain Relevance 0.61
The immunoreactivity of IL-6R and pp70S6K was not detected in the hypothalamic arcuate nucleus of rats after i.c.v. saline infusion.
Neg (not) Gene_expression (detected) of IL-6R in arcuate nucleus
4) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.15 Pain Relevance 0
Immunohistochemistry with anti-Interleukin-6 Receptor (IL-6R)-specific antibody showed that IL-6R is expressed in a majority of neurons in the arcuate nucleus (Figure 1i).
Gene_expression (expressed) of IL-6R in neurons
5) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.17 Pain Relevance 0
Immunohistochemistry with anti-Interleukin-6 Receptor (IL-6R)-specific antibody showed that IL-6R is expressed in a majority of neurons in the arcuate nucleus (Figure 1i).
Gene_expression (expressed) of IL-6R in neurons
6) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.18 Pain Relevance 0
Alternatively, IL-6 can bind to a soluble IL-6 receptor (sIL-6R), and the IL-6/sIL-6R complex can bind to the transmembrane signal-transducing subunit gp130 of cells which do not express the membrane-bound IL-6R, thus leading to IL-6 transsignalling [5].
Neg (not) Gene_expression (express) of IL-6R
7) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.86 Pain Relevance 0.49
While injection of sIL-6R alone into the normal knee joint did not influence responses to mechanical stimulation, injection of sIL-6R into the acutely inflamed knee joint caused an increase in responses.
Gene_expression (injection) of sIL-6R in knee joint
8) Confidence 0.03 Published 2007 Journal Arthritis Rheum. Section Body Doc Link 17195239 Disease Relevance 0.06 Pain Relevance 0
Hemofiltration is effective in removal of TNF-alpha, but its role is debatable for the control of IL-1, IL-6, sIL-6r and IL-8 levels.
Gene_expression (levels) of sIL-6r
9) Confidence 0.00 Published 2005 Journal Perfusion Section Abstract Doc Link 16231622 Disease Relevance 0.20 Pain Relevance 0.24

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