INT114318

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Context Info
Confidence 0.28
First Reported 2003
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.84
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6r) extracellular region (Il6r) enzyme binding (Il6r)
Anatomy Link Frequency
knee joint 2
spinal cord 2
Il6r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 8 94.96 High High
Spinal cord 2 92.80 High High
Neuropathic pain 2 92.04 High High
allodynia 4 79.60 Quite High
Dorsal horn 4 72.48 Quite High
Stimulus evoked pain 2 62.40 Quite High
Peripheral nerve injury 2 53.04 Quite High
Inflammation 2 50.00 Quite Low
unmyelinated 2 50.00 Quite Low
cytokine 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 6 94.96 High High
Neuropathic Pain 8 92.04 High High
Death 4 89.24 High High
Necrosis 2 77.24 Quite High
Cancer 2 76.88 Quite High
Injury 2 74.00 Quite High
INFLAMMATION 2 63.00 Quite High
Hypersensitivity 3 62.00 Quite High
Arthralgia 1 50.00 Quite Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggested that 6 hr pretreatment with TNF increased IL-6R expression in PC12 cells, leading to an enhancement of IL-6-induced neuroprotective action.To elucidate the role of p38 in pathological pain, we investigated whether p38 is activated in the spinal cord of the neuropathic pain model.
Spec (investigated) Positive_regulation (increased) of Gene_expression (expression) of IL-6R in spinal cord associated with pain, neuropathic pain and spinal cord
1) Confidence 0.28 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607246 Disease Relevance 0.91 Pain Relevance 0.61
TNF induced an increase of IL-6 receptor (IL-6R) expression in PC12 cells at 4-6 hr.
Positive_regulation (increase) of Gene_expression (expression) of IL-6R
2) Confidence 0.28 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607246 Disease Relevance 0.86 Pain Relevance 0.49
While injection of sIL-6R alone into the normal knee joint did not influence responses to mechanical stimulation, injection of sIL-6R into the acutely inflamed knee joint caused an increase in responses.
Positive_regulation (injection) of Gene_expression (injection) of sIL-6R in knee joint
3) Confidence 0.02 Published 2007 Journal Arthritis Rheum. Section Body Doc Link 17195239 Disease Relevance 0.06 Pain Relevance 0

General Comments

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