INT114319

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Context Info
Confidence 0.05
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, Il6r) extracellular region (TNF, Il6r) signal transduction (TNF)
plasma membrane (TNF) intracellular (TNF) enzyme binding (Il6r)
Anatomy Link Frequency
spinal cord 2
TNF (Homo sapiens)
Il6r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 3 94.96 High High
Spinal cord 1 92.80 High High
Neuropathic pain 1 92.04 High High
allodynia 2 79.60 Quite High
Dorsal horn 2 72.48 Quite High
Stimulus evoked pain 1 62.40 Quite High
Peripheral nerve injury 1 53.04 Quite High
cytokine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 2 94.96 High High
Neuropathic Pain 4 92.04 High High
Death 2 84.48 Quite High
Injury 1 74.00 Quite High
Necrosis 1 72.48 Quite High
Cancer 1 72.12 Quite High
Hypersensitivity 1 62.00 Quite High
Nervous System Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggested that 6 hr pretreatment with TNF increased IL-6R expression in PC12 cells, leading to an enhancement of IL-6-induced neuroprotective action.To elucidate the role of p38 in pathological pain, we investigated whether p38 is activated in the spinal cord of the neuropathic pain model.
TNF Spec (investigated) Positive_regulation (increased) of Gene_expression (expression) of IL-6R in spinal cord associated with pain, neuropathic pain and spinal cord
1) Confidence 0.05 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607246 Disease Relevance 0.91 Pain Relevance 0.61

General Comments

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