INT114326

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.05
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADCY6) signal transduction (ADCY6) small molecule metabolic process (ADCY6)
plasma membrane (ADCY6) cilium (ADCY6) GTPase activity (ADCY6)
ADCY6 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 96.36 Very High Very High Very High
withdrawal 1 96.04 Very High Very High Very High
opioid receptor 4 91.36 High High
dopamine receptor 2 86.72 High High
MU agonist 5 84.44 Quite High
Opioid 3 82.24 Quite High
Kinase C 5 74.48 Quite High
tolerance 2 61.20 Quite High
Analgesic 2 60.80 Quite High
Neurotransmitter 1 52.44 Quite High
Disease Link Frequency Relevance Heat
Pain 1 51.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, protein kinase signaling and phosphorylation have been implicated in the sensitization of adenylate cyclase type 6 (AC6).
Phosphorylation (phosphorylation) of AC6
1) Confidence 0.70 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 15683739 Disease Relevance 0 Pain Relevance 0.26
Raf-1 in turn phosphorylates and sensitizes the native adenylyl cyclase VI isoenzyme in hDOR/CHO cells, causing a rebound increase in forskolin-stimulated cAMP formation upon agonist withdrawal.
Phosphorylation (phosphorylates) of cyclase VI isoenzyme associated with agonist and withdrawal
2) Confidence 0.04 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607258 Disease Relevance 0.05 Pain Relevance 0.84

General Comments

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