INT114327

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 20.87
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)
cell proliferation (RAF1) signal transduction (RAF1) nucleus (RAF1)
Anatomy Link Frequency
reticulum 2
node 1
RAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 16 100.00 Very High Very High Very High
opioid receptor 4 93.36 High High
Central nervous system 2 92.00 High High
MU agonist 5 86.44 High High
agonist 3 85.84 High High
Inflammation 149 85.32 High High
withdrawal 1 85.20 High High
Opioid 4 81.84 Quite High
dopamine receptor 4 80.04 Quite High
Spinal cord 5 75.60 Quite High
Disease Link Frequency Relevance Heat
Hepatitis 11 100.00 Very High Very High Very High
Thyroid Neoplasm 1099 99.84 Very High Very High Very High
Hepatitis C Virus Infection 191 99.48 Very High Very High Very High
Carcinoid 28 99.28 Very High Very High Very High
Cancer 505 99.26 Very High Very High Very High
Dengue 64 99.16 Very High Very High Very High
Dengue Hemorrhagic Fever 88 98.60 Very High Very High Very High
Hepatocellular Cancer 95 96.36 Very High Very High Very High
Syndrome 19 96.28 Very High Very High Very High
Infection 80 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PLX4032 is also known for its paradoxical effect on cells with wild-type BRAF, in which RAF1 is activated (reviewed in [6]).
Positive_regulation (activated) of RAF1
1) Confidence 0.51 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917408 Disease Relevance 0.91 Pain Relevance 0
Fourteen sequences were obtained from 8 isolates from Oaxaca and 6 from Veracruz for the C-prM fragment (11 with DF and 3 with DHF); 7 sequences were obtained from 5 Oaxaca isolates and 2 from Veracruz isolates for the MTase domain (NS573) fragment (4 with DF and 3 with DHF); 18 sequences were obtained from 7 Oaxaca isolates and 11 from Veracruz isolates for the RdRp domain (NS573) fragment (12 with DF and 6 with DHF); 7 sequences were obtained from 7 Oaxaca isolates for the helicase domain fragment (6 with DF and 1 with DHF).
Positive_regulation (isolates) of NS5 associated with dengue and dengue hemorrhagic fever
2) Confidence 0.49 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2515156 Disease Relevance 1.07 Pain Relevance 0
To interpret the experimental data, we propose that chronic hDOR activaton leads to activation of multiple redundant signaling pathways that converge to activate the protein kinase, Raf-1.
Positive_regulation (activate) of Raf-1
3) Confidence 0.45 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607258 Disease Relevance 0.05 Pain Relevance 0.90
In this study, we investigated a novel treatment for carcinoid tumor cell growth based on pharmacologic Raf-1 activation using the compound ZM336372.
Positive_regulation (activation) of Raf-1 associated with carcinoid
4) Confidence 0.42 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15956248 Disease Relevance 0.93 Pain Relevance 0.05
We have previously shown that activation of the Raf-1 signaling pathway can suppress hormone production in carcinoid tumor cells.
Positive_regulation (activation) of Raf-1 associated with carcinoid
5) Confidence 0.42 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15956248 Disease Relevance 0.87 Pain Relevance 0
Decreased intracellular reactive oxygen species, increased intracellular glutathione, and activation of Raf-1/MEK1/ERK1/2 pathway are observed with the combination treatment 49.
Positive_regulation (activation) of Raf-1
6) Confidence 0.34 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.78 Pain Relevance 0.10
These data indicate that, although PKC and Raf1 are not required for sensitization, activation of the PKC-Raf1 pathway robustly potentiated D2L receptor-mediated sensitization of AC6.
Neg (not) Positive_regulation (required) of Raf1 associated with kinase c
7) Confidence 0.26 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 15683739 Disease Relevance 0 Pain Relevance 0.39
These data indicate that, although PKC and Raf1 are not required for sensitization, activation of the PKC-Raf1 pathway robustly potentiated D2L receptor-mediated sensitization of AC6.
Positive_regulation (activation) of Raf1 associated with kinase c
8) Confidence 0.24 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 15683739 Disease Relevance 0 Pain Relevance 0.39
CEGG carried out the RT-PCR assays using RNA isolates from passages 1, 2 and 3 to determine serotype and to amplify the NS5 and NS3 genes for genotyping, and co-wrote the manuscript.
Positive_regulation (amplify) of NS5
9) Confidence 0.24 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2515156 Disease Relevance 0 Pain Relevance 0
In addition, antibody to hepatitis C virus in these patients were detected as controls by using hepatitis C Virus encoded Antigen (Recombinant c22-3, c200 and NS5) with ORTHO HCV Version 3.0 ELISA Test System (Ortho-Clinical Diagnostics) according to the manufacturer's recommendations.



Positive_regulation (using) of NS5 associated with hepatitis c virus infection and hepatitis
10) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.48 Pain Relevance 0
ZM336372, originally identified as a potent and specific inhibitor of Raf isoforms [45], has been shown to paradoxically demonstrate a >100-fold induction of Raf-1 activity in NE cell culture systems [45, 46].
Positive_regulation (induction) of Raf-1
11) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.71 Pain Relevance 0
Utilizing an estradiol-inducible estrogen receptor fused with the catalytic domain of the Raf-1 fusion protein, we have shown that activation of the Raf-1 pathway is associated with a reduction in NE hormones such as calcitonin and CgA [39].
Positive_regulation (activation) of Raf-1
12) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.98 Pain Relevance 0
These data clearly demonstrate that although activation of the Raf-1 signaling pathway is growth promoting in several cancers, in certain cell-specific subtypes, Raf-1 activation inhibits tumorigenesis.
Positive_regulation (activation) of Raf-1 associated with cancer
13) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.80 Pain Relevance 0
Despite the fact that methods to deliver activated Raf-1 to MTC cells are limited, pharmacologic activators of the Raf-1 pathway are currently under investigation.
Positive_regulation (activated) of Raf-1 associated with thyroid neoplasm
14) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.78 Pain Relevance 0
Recently, we have shown that Raf-1 activation in human MTC cells results in phosphorylation and subsequent inactivation of GSK-3ß [30]; likewise, inactivation of GSK-3ß by phosphorylation results in MTC growth inhibition both in vitro and in vivo.
Positive_regulation (activation) of Raf-1 associated with thyroid neoplasm
15) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.86 Pain Relevance 0
In MTC cells in vitro, Kunnimalaiyaan et al. [47] have demonstrated that ZM336372 treatment resulted in increasing Raf-1 activation as measured by phosphorylation of ERK1/2.
Positive_regulation (activation) of Raf-1 associated with thyroid neoplasm
16) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.64 Pain Relevance 0
These data clearly demonstrate that although activation of the Raf-1 signaling pathway is growth promoting in several cancers, in certain cell-specific subtypes, Raf-1 activation inhibits tumorigenesis.
Positive_regulation (activation) of Raf-1 associated with cancer
17) Confidence 0.20 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.81 Pain Relevance 0
Although activation of this signaling pathway is commonly considered to be growth promoting in several cancers, in certain cell-specific subtypes, raf-1 activation results in growth suppression (Kunnimalaiyaan et al 2007b).
Positive_regulation (activation) of raf-1 associated with cancer
18) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.06 Pain Relevance 0
At our institution, Kunnimalaiyaan et al (2007b) found that raf-1 activation in human MTC cells (TT cells) results in phosphorylation of GSK-3?
Positive_regulation (activation) of raf-1 associated with thyroid neoplasm
19) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 0.63 Pain Relevance 0
Specifically, activation of the raf-1 signaling pathway in MTC has been shown to lead to significant morphologic differentiation and growth reduction both in vitro and in a mouse xenograft TT model in vivo (Ravi et al 1998, 1999; Park et al 2003; Vaccaro et al 2006).
Positive_regulation (activation) of raf-1 associated with thyroid neoplasm
20) Confidence 0.17 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621417 Disease Relevance 1.03 Pain Relevance 0

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