INT114330

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 25.58
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MPZ) plasma membrane (MPZ)
Anatomy Link Frequency
Tooth 3
band 2
plasma 1
liver 1
T cell 1
MPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 490 99.36 Very High Very High Very High
Catecholamine 1 96.76 Very High Very High Very High
imagery 14 95.88 Very High Very High Very High
Demyelination 2 93.12 High High
cva 19 92.20 High High
Peripheral nervous system 7 89.92 High High
Pain 35 88.68 High High
Neuropathic pain 1 86.80 High High
cytokine 57 80.08 Quite High
nociceptor 2 78.52 Quite High
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 1604 100.00 Very High Very High Very High
Charcot Marie Tooth Disease 64 100.00 Very High Very High Very High
Mouth Disease 43 100.00 Very High Very High Very High
Neuropathy 15 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 15 99.76 Very High Very High Very High
Syndrome 111 99.48 Very High Very High Very High
Dengue 725 99.40 Very High Very High Very High
Shock 151 99.40 Very High Very High Very High
INFLAMMATION 551 99.36 Very High Very High Very High
Hemorrhage 57 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, the mid-term follow-up after MVD clearly shows that the causal treatment for TN can be successfully applied to patients with TN plus CMT.


CMT Binding (applied) of in CMT
1) Confidence 0.32 Published 2008 Journal Zentralbl. Neurochir. Section Body Doc Link 18666057 Disease Relevance 0 Pain Relevance 0
A genetic test disclosed a heterozygous mutation of myelin protein zero (MPZ); p.Thr124Met.
MPZ Binding (mutation) of
2) Confidence 0.32 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 19928689 Disease Relevance 0.79 Pain Relevance 0.16
When comparing our results to those of colleagues who reported gene or protein signatures associated with DSS, we identified some transcripts encoding proteins considered putative markers of severe dengue.
DSS Binding (associated) of associated with dengue and dengue hemorrhagic fever
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 0.99 Pain Relevance 0.16
Further investigations should consider possible associations between DSS and allelic variants of such genes.
DSS Binding (associations) of associated with dengue hemorrhagic fever
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.57 Pain Relevance 0.03
Hence, it is difficult to set treatment goals for lowering the PTI or MPP to a constant threshold.
MPP Binding (lowering) of
5) Confidence 0.31 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1712337 Disease Relevance 0.14 Pain Relevance 0.31
In particular, several under-expressed but partially redundant signaling canonical pathways related to T lymphocyte activation were identified, of which the T cell receptor (TCR) signaling pathway (Figure 3), which has the strongest association with the DSS-gene signature.
DSS-gene Binding (association) of in T cell associated with dengue hemorrhagic fever
6) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.13 Pain Relevance 0.16
Using multi-way analysis of variance (ANOVA) and adjustment of p-values to control the False Discovery Rate (FDR<10%), we identified a signature of 2959 genes differentiating DSS patients from both DF and DHF, and showed a strong association of this DSS-gene signature with the dengue disease phenotype.
DSS-gene Binding (association) of associated with dengue, dengue hemorrhagic fever and disease
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2907396 Disease Relevance 1.78 Pain Relevance 0.09
The Val102fs mutation of the myelin protein zero gene (MPZ) has been associated with Charcot-Marie-Tooth disease type 1B (CMT1B).
Charcot-Marie-Tooth disease type 1B Binding (associated) of in Tooth associated with charcot marie tooth disease and mouth disease
8) Confidence 0.25 Published 2009 Journal Neuromuscul. Disord. Section Abstract Doc Link 19906531 Disease Relevance 1.06 Pain Relevance 0.12
The Val102fs mutation of the myelin protein zero gene (MPZ) has been associated with Charcot-Marie-Tooth disease type 1B (CMT1B).
CMT1B Binding (associated) of in Tooth associated with charcot marie tooth disease and mouth disease
9) Confidence 0.25 Published 2009 Journal Neuromuscul. Disord. Section Abstract Doc Link 19906531 Disease Relevance 1.07 Pain Relevance 0.12
In particular, the PPARA gene that negatively regulates the formation of lipid-laden Mo/Mac [87] has decreased abundance in DSS patients.
DSS Binding (abundance) of associated with dengue hemorrhagic fever
10) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 0.84 Pain Relevance 0.13
Filtering genes from those having the highest to the lowest statistical association with the disease phenotype variable (Table S2), relying on results from multi-way and local ANOVA revealed that the individual genes having the strongest association with the DSS phenotype subtype are, for a large part, related to innate immunity, inflammation and host lipid metabolism, a finding confirmed when the whole 2959 genes of the DSS-gene signature were processed through the knowledge-based IPA software.
DSS Binding (association) of associated with inflammation, dengue hemorrhagic fever and disease
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.57 Pain Relevance 0.09
Another patient with DSS had a Gly123Cys, while a patient with CMT type 1 had a Gly123Ser amino acid substitution [6,18].
CMT type 1 Binding (patient) of associated with syndrome
12) Confidence 0.10 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 0.78 Pain Relevance 0
Both CMT1 and CMT2 have been recognized to be genetically heterogeneous.
CMT1 Binding (recognized) of
13) Confidence 0.08 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1524942 Disease Relevance 0.62 Pain Relevance 0.04
DSS crosslinking was performed for 20 min on room temperature.
DSS Binding (crosslinking) of
14) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0 Pain Relevance 0
We reasoned that we should be able to detect such multimers as clear and dominant band if we apply more intense crosslinking (DSS + PDM for 1 h) or if we solubilize cells with non-ionic detergent after DSS crosslinking.
DSS Binding (crosslinking) of in band
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0 Pain Relevance 0
We reasoned that we should be able to detect such multimers as clear and dominant band if we apply more intense crosslinking (DSS + PDM for 1 h) or if we solubilize cells with non-ionic detergent after DSS crosslinking.
DSS Spec (clear) Binding (crosslinking) of in band
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0 Pain Relevance 0
We also verified the expression of some transcripts that were associated with DSS.
DSS Binding (associated) of associated with dengue hemorrhagic fever
17) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.98 Pain Relevance 0.04
Halstead et al. pointed out that infants are a high risk group for DHF/DSS, and need to be studied to further understand primary dengue infection [30].


DSS Binding (group) of associated with dengue, dengue hemorrhagic fever and infection
18) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.73 Pain Relevance 0
Inflammatory neuropathy has previously been recognized in patients with hereditary neuropathy, with uncharacterized genetic defects and with CMT1B.
CMT1B Binding (recognized) of associated with neuropathy and inflammation
19) Confidence 0.03 Published 2004 Journal Brain Section Abstract Doc Link 14607795 Disease Relevance 1.85 Pain Relevance 0.32
Considering such reproducibility in different study periods, within the same ethnic group and in the same region, give us the confidence to assign an association of HLA-A*24 and DHF, DSS even though our P value just reached the significant level before Bonferoni correction.


DSS Binding (association) of associated with dengue hemorrhagic fever
20) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.42 Pain Relevance 0

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