INT114364

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Context Info
Confidence 0.05
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.85
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hmgb1, TNF) extracellular region (Hmgb1, TNF) cell morphogenesis (Hmgb1)
intracellular (TNF) extracellular matrix organization (TNF) DNA binding (Hmgb1)
Anatomy Link Frequency
brain 2
Hmgb1 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 46 100.00 Very High Very High Very High
Inflammation 27 100.00 Very High Very High Very High
Intracerebroventricular 3 99.60 Very High Very High Very High
Nicotine 40 89.72 High High
intrathecal 1 86.64 High High
agonist 24 84.64 Quite High
allodynia 1 82.16 Quite High
Central nervous system 6 75.00 Quite High
chemokine 16 53.20 Quite High
ischemia 19 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 100.00 Very High Very High Very High
Appetite Loss 1 98.44 Very High Very High Very High
Fever 2 98.00 Very High Very High Very High
Injury 71 97.92 Very High Very High Very High
Necrosis 8 95.72 Very High Very High Very High
Cancer 3 95.36 Very High Very High Very High
Sepsis 5 92.88 High High
Neuropathic Pain 1 82.16 Quite High
Death 3 73.88 Quite High
Disease 1 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracerebroventricular (ICV) administration of HMGB1 has been shown to increase TNF expression in mouse brain and induce aphagia and taste aversion.
HMGB1 Positive_regulation (increase) of Gene_expression (expression) of TNF in brain associated with appetite loss and intracerebroventricular
1) Confidence 0.05 Published 2003 Journal Cytokine Section Abstract Doc Link 14609567 Disease Relevance 0.56 Pain Relevance 0.52
In vitro, necrotic cells as well as purified HMGB-1 trigger the production of pro-inflammatory cytokine TNF-?
HMGB-1 Positive_regulation (trigger) of Gene_expression (production) of TNF associated with inflammation and cytokine
2) Confidence 0.02 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 1.29 Pain Relevance 0.53

General Comments

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