INT114371

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.70
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tcf7l2) cytosol (Tcf7l2) nucleoplasm (Tcf7l2)
nucleus (Tcf7l2) DNA binding (Tcf7l2) transcription factor binding (Tcf7l2)
Anatomy Link Frequency
T-cell 1
Tcf7l2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 3 71.12 Quite High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 1 99.04 Very High Very High Very High
Colon Cancer 3 89.44 High High
Adenoma 1 81.76 Quite High
Apoptosis 2 78.64 Quite High
Colorectal Cancer 2 75.00 Quite High
INFLAMMATION 1 63.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is consistent with our earlier finding that inhibition of the beta-catenin:T-cell factor 4 (Tcf-4) pathway by the adenomatous polyposis coli protein down-regulates survivin expression and with recent evidence that sulindac induces beta-catenin degradation, which would reduce Tcf-4 activation.
Negative_regulation (inhibition) of T-cell factor 4 in T-cell associated with familial adenomatous polyposis
1) Confidence 0.05 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610217 Disease Relevance 0.70 Pain Relevance 0.20

General Comments

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