INT114381

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.25
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2a5)
Anatomy Link Frequency
lateral 2
LNG 2
Cyp2a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 20 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 98.04 Very High Very High Very High
Toxicity 20 97.16 Very High Very High Very High
Embryonic Lethality 4 83.84 Quite High
Targeted Disruption 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of CYP2G1 expression, and the associated decrease in the hepatic expression of CYP2A5, did not decrease systemic clearance, extent of hepatotoxicity, or OM toxicity of acetaminophen (AP).
Negative_regulation (loss) of Gene_expression (expression) of CYP2A5 associated with toxicity, paracetamol and hepatotoxicity
1) Confidence 0.55 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610229 Disease Relevance 0.58 Pain Relevance 0.43
Unexpectedly, a significant reduction in the expression of the Cyp2a5 gene was found in the liver, the lateral nasal gland (LNG), and, to a lesser extent, the kidney of adult Cyp2g1-null mice.
Negative_regulation (reduction) of Gene_expression (expression) of Cyp2a5 in lateral
2) Confidence 0.55 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610229 Disease Relevance 0.54 Pain Relevance 0.35
Paradoxically, the LNG did not have detectable CYP2G1, and the decrease in LNG CYP2A5 expression in the Cyp2g1-null mice was not accompanied by decreases in microsomal AP metabolism.
Negative_regulation (decrease) of Gene_expression (expression) of LNG CYP2A5 in LNG associated with paracetamol
3) Confidence 0.48 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610229 Disease Relevance 0.55 Pain Relevance 0.46
The loss of CYP2G1 expression, and the associated decrease in the hepatic expression of CYP2A5, did not decrease systemic clearance, extent of hepatotoxicity, or OM toxicity of acetaminophen (AP).
Negative_regulation (decrease) of Gene_expression (expression) of CYP2A5 associated with toxicity, paracetamol and hepatotoxicity
4) Confidence 0.41 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610229 Disease Relevance 0.58 Pain Relevance 0.43

General Comments

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