INT114383

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2a5)
Anatomy Link Frequency
gland 2
Cyp2a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 98.82 Very High Very High Very High
Bile 1 71.48 Quite High
depression 8 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 6 99.00 Very High Very High Very High
Targeted Disruption 2 97.42 Very High Very High Very High
Embryonic Lethality 1 87.12 High High
Disease 3 65.88 Quite High
Newborn Jaundice 1 64.88 Quite High
Drug Induced Neurotoxicity 1 64.04 Quite High
Hepatotoxicity 1 57.88 Quite High
Stress 29 52.52 Quite High
Infection 62 50.08 Quite High
Malaria 45 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression.
Regulation (effects) of Gene_expression (expression) of Cyp2a5 in gland associated with targeted disruption, toxicity and paracetamol
1) Confidence 0.58 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 14610229 Disease Relevance 0.54 Pain Relevance 0.27
A hypothesis was advanced that a coordinated regulation of CYP2a5 and HO-1 expressions contributes to achieving a balance between bilirubin production and elimination.
Regulation (regulation) of Gene_expression (expressions) of CYP2a5
2) Confidence 0.22 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.36 Pain Relevance 0.04

General Comments

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