INT11439

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Context Info
Confidence 0.69
First Reported 1981
Last Reported 2011
Negated 4
Speculated 1
Reported most in Abstract
Documents 105
Total Number 106
Disease Relevance 62.63
Pain Relevance 37.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
CSF 22
outflow 8
brain 6
macrophages 4
granulocyte 4
Csf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 508 100.00 Very High Very High Very High
cytokine 161 100.00 Very High Very High Very High
intrathecal 133 100.00 Very High Very High Very High
Pain 124 100.00 Very High Very High Very High
excitatory amino acid 35 100.00 Very High Very High Very High
Kinase C 8 100.00 Very High Very High Very High
Inflammation 231 99.96 Very High Very High Very High
gABA 36 99.96 Very High Very High Very High
Glutamate 125 99.92 Very High Very High Very High
Hyperalgesia 22 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 138 100.00 Very High Very High Very High
Injury 118 99.98 Very High Very High Very High
Sleep Disorders 16 99.98 Very High Very High Very High
INFLAMMATION 288 99.96 Very High Very High Very High
Leukocytosis 5 99.96 Very High Very High Very High
Hyperalgesia 28 99.90 Very High Very High Very High
Bacteremia 9 99.90 Very High Very High Very High
Hydrocephalus 762 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 109 99.84 Very High Very High Very High
Demyelinating Disease 74 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that chronic neuropathic pain produces increased CSF levels of secretogogues for chromaffin cells, and illustrates the importance of host microenvironmental factors in determining graft function.
Positive_regulation (increased) of CSF in CSF associated with neuropathic pain
1) Confidence 0.69 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10825645 Disease Relevance 0.56 Pain Relevance 0.71
Oral fluoxetine administration (5 mg/kg) for 21 days also elevated the CSF GABA levels by approximately 2-fold (P < 0.05).
Positive_regulation (elevated) of CSF associated with gaba and fluoxetine
2) Confidence 0.68 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17486443 Disease Relevance 0.06 Pain Relevance 1.14
It is not known if both phases of HS, the ischemic and the reperfusion phase, are required for G-CSF mRNA induction.
Positive_regulation (induction) of G-CSF mRNA associated with hemorrhagic shock
3) Confidence 0.67 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 0.68 Pain Relevance 0.23
Upregulation of G-CSF mRNA relative to controls occurred only in animals undergoing resuscitated HS and not in ones subjected to unresuscitated HS.
Positive_regulation (Upregulation) of G-CSF mRNA associated with hemorrhagic shock
4) Confidence 0.67 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 1.06 Pain Relevance 0.31
Using semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR), we demonstrated that G-CSF mRNA was induced in the lung and liver of shock animals above the level observed in control animals.
Positive_regulation (induced) of G-CSF mRNA in liver associated with shock
5) Confidence 0.67 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 1.05 Pain Relevance 0.31
Electroconvulsive shock (ECS) produced a significant elevation in CSF content but only after a course of chronic administration; a single acute ECS produced no increase.
Positive_regulation (elevation) of CSF in CSF associated with shock
6) Confidence 0.66 Published 1988 Journal Brain Res. Section Abstract Doc Link 2905617 Disease Relevance 0.55 Pain Relevance 0.26
Elevated CSF concentrations of fibroblast growth factor (FGF-2) are associated with hydrocephalus and when FGF-2 is introduced into the ventricular system of rats, CSF formation rate declines and CSF outflow resistance increases [3].
Positive_regulation (increases) of CSF in outflow associated with hydrocephalus
7) Confidence 0.65 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.65 Pain Relevance 0.15
PCNA was increased in the EPO and GM-CSF+ EPO groups, while there was no increase in the GM-CSF group.


Neg (no) Positive_regulation (increase) of GM-CSF
8) Confidence 0.64 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
This study provides additional evidence for the mechanism of action of MK-801, showing that MK-801 induces hyperalgesia with parallel increase in CSF EAAs levels.
Positive_regulation (increase) of CSF associated with hyperalgesia and excitatory amino acid
9) Confidence 0.61 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18854198 Disease Relevance 0.75 Pain Relevance 1.28
However, MK-801 (0.5 mg/kg) induced hyperalgesia and increased the CSF EAAs levels; both effects were prevented by guanosine, riluzole or morphine.
Positive_regulation (increased) of CSF associated with hyperalgesia, morphine and excitatory amino acid
10) Confidence 0.61 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18854198 Disease Relevance 0.73 Pain Relevance 1.44
The NMDA antagonist MK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats: reversal by guanosine.
Positive_regulation (increases) of CSF associated with hyperalgesia, antagonist and excitatory amino acid
11) Confidence 0.61 Published 2009 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 18854198 Disease Relevance 0.69 Pain Relevance 1.28
Elevated CSF concentrations of fibroblast growth factor (FGF-2) are associated with hydrocephalus and when FGF-2 is introduced into the ventricular system of rats, CSF formation rate declines and CSF outflow resistance increases [3].
Positive_regulation (concentrations) of CSF in fibroblast associated with hydrocephalus
12) Confidence 0.57 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.61 Pain Relevance 0.13
During this period, PGE2 is associated with hypothalamic maturation processes [24] and an increase in CSF PGE2 induces respiratory depression [reviewed in [11,12]].
Positive_regulation (increase) of CSF in respiratory associated with depression and respiratory failure
13) Confidence 0.56 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2292143 Disease Relevance 0.28 Pain Relevance 0.09
The main findings were (1) Chronic pain experiments in animals showed that the stimulation of the anterior part of the PVN increased OT concentration and produced analgesia states, as measured by von Frey, cold, and heat plantar tests. (2) Differential effects were produced by electrical stimulation of the anterior or posterior regions of the PVN; electrical stimulation of the anterior part of the PVN enhanced the OT concentration in CSF and plasma, and it also increased OT protein concentrations in the spinal cord tissue; in contrast, the stimulation of the posterior part of the PVN only increased OT concentrations in CSF.
Positive_regulation (increased) of CSF in PVN associated with lasting pain, spinal cord and analgesia
14) Confidence 0.53 Published 2008 Journal Pain Section Abstract Doc Link 18823708 Disease Relevance 0.43 Pain Relevance 0.77
The present study reveals that an increasing of CSF EAAs concentration might be responsible for the losing of morphine's antinociceptive effect in morphine tolerant rats.
Positive_regulation (increasing) of CSF associated with antinociceptive, morphine and excitatory amino acid
15) Confidence 0.48 Published 2004 Journal Brain Res. Section Abstract Doc Link 14672815 Disease Relevance 0 Pain Relevance 1.02
Elevated CSF total protein concentration was related to chronic leg pain, leg pain, and subjective physical disability at follow-up.
Positive_regulation (Elevated) of CSF in leg associated with pain
16) Confidence 0.47 Published 1997 Journal J Spinal Disord Section Abstract Doc Link 9438816 Disease Relevance 0.72 Pain Relevance 0.56
GM-CSF is a haematopoietic growth factor that apart from stimulating the proliferation and differentiation of myeloid bone marrow progenitor cells, also enhances the function of mature macrophages that are induced to secrete various cytokines including IL-6 and TNF-a [13].
Positive_regulation (induced) of GM-CSF in macrophages associated with cytokine
17) Confidence 0.46 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.50 Pain Relevance 0.16
Granulocyte colony-stimulating factor (G-CSF) is a glycopeptide which stimulates the granulocyte lineage and stem cells.
Positive_regulation (stimulating) of G-CSF in granulocyte
18) Confidence 0.45 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2386131 Disease Relevance 0.53 Pain Relevance 0.22
The beta-ELIR in CSF was elevated at 5 and 10 min, followed by a significant decrease at 30 min after the learning trial in rats exposed to a footshock of 1.0 mA.
Positive_regulation (elevated) of CSF in CSF
19) Confidence 0.44 Published 1996 Journal Psychoneuroendocrinology Section Abstract Doc Link 8983087 Disease Relevance 0.22 Pain Relevance 0.07
An increase in beta-ELIR in CSF may be highly associated with stressful and emotional responses during behavioral training.
Positive_regulation (increase) of CSF in CSF
20) Confidence 0.44 Published 1996 Journal Psychoneuroendocrinology Section Abstract Doc Link 8983087 Disease Relevance 0.26 Pain Relevance 0

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