INT114394

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.09
Pain Relevance 7.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (Nlrp1a) nucleus (Nlrp1a) enzyme binding (Nlrp1a)
Anatomy Link Frequency
NAc 2
NAcS 2
neurons 2
gill 2
Nlrp1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 25 100.00 Very High Very High Very High
Morphine 23 100.00 Very High Very High Very High
Nucleus accumbens 21 100.00 Very High Very High Very High
cocaine 23 99.92 Very High Very High Very High
Ventral tegmentum 19 99.26 Very High Very High Very High
gABA 19 99.20 Very High Very High Very High
opiate 12 98.92 Very High Very High Very High
Glutamate 4 98.64 Very High Very High Very High
Dynorphin 4 98.08 Very High Very High Very High
agonist 11 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 15 99.84 Very High Very High Very High
Drug Dependence 15 95.68 Very High Very High Very High
Opiate Addiction 8 77.12 Quite High
Substance Withdrawal Syndrome 1 65.20 Quite High
Alcohol Addiction 4 54.64 Quite High
Neuroblastoma 1 16.76 Low Low
Convulsion 1 9.20 Low Low
Recurrence 5 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Cannabis Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of cocaine to increase NAc DA levels was reduced in KO.
Negative_regulation (reduced) of Positive_regulation (increase) of NAc in NAc associated with targeted disruption, nucleus accumbens, dopamine and cocaine
1) Confidence 0.42 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16420432 Disease Relevance 0.55 Pain Relevance 1.33
In conclusion, GABA(B) receptor stimulation in the VTA blocked opiate-induced motor stimulation and motor sensitization by inhibiting the activation of NAcS neurons.
Negative_regulation (inhibiting) of Positive_regulation (activation) of NAcS in neurons associated with ventral tegmentum, gaba and opiate
2) Confidence 0.09 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610238 Disease Relevance 0 Pain Relevance 1.50
Intra-VTA baclofen administered only on day 9 blocked the expression of morphine-induced motor sensitization and Fos activation in the NAcS.
Negative_regulation (blocked) of Positive_regulation (activation) of NAcS in NAcS associated with ventral tegmentum and morphine
3) Confidence 0.08 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610238 Disease Relevance 0 Pain Relevance 1.89
Expression of gill glutamate transporter, gamma interferon-inducible lysosomal thiol reductase (GILT-1) mRNA was found to be increased in the striatum and NAc of morphine-dependent rats and decreased in morphine-withdrawn rats.[9] A glutamate transporter activator inhibited the development of physical and psychological dependence on morphine.[9]

Other neurotransmitter systems

Negative_regulation (decreased) of Positive_regulation (increased) of NAc in gill associated with nucleus accumbens, neurotransmitter, glutamate, psychological dependence and morphine
4) Confidence 0.01 Published 2007 Journal Indian Journal of Psychiatry Section Body Doc Link PMC2917090 Disease Relevance 0.54 Pain Relevance 2.66

General Comments

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