INT114406

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Context Info
Confidence 0.72
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 6.83
Pain Relevance 9.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
ventricle 1
neurons 1
striatum 1
fibroblast 1
motor neurons 1
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 841 100.00 Very High Very High Very High
agonist 137 99.96 Very High Very High Very High
B1 receptor 2 99.96 Very High Very High Very High
depression 127 99.66 Very High Very High Very High
Antinociceptive 66 99.64 Very High Very High Very High
cocaine 420 99.56 Very High Very High Very High
bradykinin 2 99.56 Very High Very High Very High
Spinal cord 52 99.36 Very High Very High Very High
antagonist 170 99.02 Very High Very High Very High
medulla 100 98.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 49 99.86 Very High Very High Very High
Depression 134 99.66 Very High Very High Very High
Nociception 25 99.44 Very High Very High Very High
Diabetes Mellitus 20 99.08 Very High Very High Very High
Nervous System Injury 12 98.44 Very High Very High Very High
Hypoxia 59 98.42 Very High Very High Very High
INFLAMMATION 20 98.00 Very High Very High Very High
Herpes Simplex Virus 1 97.48 Very High Very High Very High
Hyperalgesia 13 97.32 Very High Very High Very High
Disease 14 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bradykinin (BK) B(1) receptors (BKB1-R) are over-expressed in pathological conditions including diabetes, and were reported to play a role in hyperglycemia, renal abnormalities, and altered vascular permeability associated with type 1 diabetes.
Gene_expression (expressed) of BKB1-R associated with hyperglycemia, congenital anomalies, diabetes mellitus and bradykinin
1) Confidence 0.72 Published 2003 Journal Peptides Section Abstract Doc Link 14612183 Disease Relevance 1.01 Pain Relevance 0.41
We found that adenosine, a neuromodulator with anti-nociceptive properties, was released during acupuncture in mice and that its anti-nociceptive actions required adenosine A1 receptor expression.
Gene_expression (expression) of A1 receptor associated with nociception, adenocard and acupuncture
2) Confidence 0.68 Published 2010 Journal Nat. Neurosci. Section Abstract Doc Link 20512135 Disease Relevance 0.44 Pain Relevance 0.91
In fact, expressional levels of the A1AR are higher in the atrium as compared to the ventricle [33], [34].
Gene_expression (expressional) of A1AR in ventricle
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.29 Pain Relevance 0.37
mNT5E has long lasting antinociceptive effects that are A1R dependent
Gene_expression (dependent) of A1R associated with antinociceptive
4) Confidence 0.66 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0.28
Thus, deficiencies in adenosine production or A1R signaling cause similar behavioral phenotypes.
Gene_expression (production) of A1R associated with adenocard
5) Confidence 0.66 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 1.14 Pain Relevance 1.02
The same phenomenon was also found in the female offspring of the A1R Hz mothers after the cocaine stimulation (interaction mother's genotype p?
Gene_expression (mothers) of A1R Hz associated with cocaine
6) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.07 Pain Relevance 0.37
After stimulation with cocaine we could still observe modifications caused by the absence of A1R on the offsprings' reaction to the psychostimulant (Figure 6C) (accumulated beam breaks from 46–135 min in Ha: WT grandmother WT mother WT offspring: 39.8±3.3, n?
Neg (absence) Gene_expression (absence) of A1R associated with cocaine
7) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.07 Pain Relevance 0.30
Autoradiography with the selective A1R antagonist [3H]DPCPX determined that half of the number of A1R present in A1R Hz mice than in the WT when the area of nucleus accumbens was examined (Figure 4) and striatum (not shown).
Gene_expression (present) of A1R in striatum associated with nucleus accumbens and antagonist
8) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0 Pain Relevance 0.36
A statistically significant increase in locomotion was, however, displayed by female A1R Hz group compared to their WT controls (Figure 5B).
Gene_expression (group) of A1R Hz
9) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0 Pain Relevance 0.16
Interaction between A1Rs and GABAA receptors
Gene_expression (receptors) of A1R
10) Confidence 0.65 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.62
Motor side-effects could be due to widespread expression of A1R throughout the spinal cord, including relatively high-level expression in motor neurons [38].
Gene_expression (expression) of A1R in motor neurons associated with spinal cord
11) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.38 Pain Relevance 0.99
In fact, in transgenic mice, overexpressing the A1AR, it was shown that the ?
Gene_expression (overexpressing) of A1AR associated with targeted disruption
12) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2727950 Disease Relevance 0.30 Pain Relevance 0.21
Accordingly, this study determined whether the blocking the postsynaptic currents/potentials evoked by activation of GABAA and glycine receptors may alter the extent of network depression observed during A1R activation.
Gene_expression (activation) of A1R associated with depression
13) Confidence 0.59 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.25 Pain Relevance 0.05
In brainstem-spinal cord preparations Herlenius and Lagercrantz found that A1R activation decreased the Vm of expiratory neurons but did not affect Rin or Vm of inspiratory neurons [23].
Gene_expression (activation) of A1R in neurons associated with medulla and spinal cord
14) Confidence 0.59 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0.14
Although adenosine represents only one of numerous variables that contribute to hypoxic depression of respiratory network output, the data presented here verify that A1R activation is sufficient to overcome potential increases in network excitability caused by reduction in GABA and glycine transmission and in so doing depress preBötC bursting [c.f. [22-24,44]].
Gene_expression (activation) of A1R in respiratory associated with gaba, adenocard, depression and hypoxia
15) Confidence 0.59 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.42 Pain Relevance 0.42
In our study, we have controlled for the mother's and grandmother's genotype in A1R Hz offspring but not for the father's or grandfather's genotype.
Gene_expression (offspring) of A1R Hz
16) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.05 Pain Relevance 0.06
17; A1R Hz 113.6±1.6, n?
Gene_expression (113.6) of A1R Hz
17) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0 Pain Relevance 0.19
21 and A1R Hz 94.0±9.8, n?
Gene_expression (94.0) of A1R Hz
18) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0 Pain Relevance 0.24
When tested for the spontaneous activity A1R Hz male group did not show a significant increase in locomotion compared to the WT untreated group (Figure 5A) (45 min of habituation 1, Ha: WT H2O 110.7±1.0, n?
Gene_expression (group) of A1R Hz
19) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0 Pain Relevance 0.23
9; A1R Hz grandmother WT mother WT offspring: 51.7±3.8, n?
Gene_expression (offspring) of A1R Hz
20) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.07 Pain Relevance 0.33

General Comments

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