INT114411

Context Info Confidence 0.22 First Reported 2003 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 5 Disease Relevance 0.14 Pain Relevance 0.66

Anatomy Link Frequency stomach 4 parietal cells 2 HCL1 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 12 93.84 Chronic nonmalignant pain 4 50.00 transdermal 2 50.00 Oxycodone 2 50.00 Pain 2 10.00 Analgesic 2 5.00 long acting opioid 2 5.00

Disease Link Frequency Relevance Heat Pain 4 69.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The inclusion criteria for the study were (1) diagnosis of chronic nonmalignant pain, (2) prescription for and current use of either transdermal fentanyl or oxycodone HCl controlled-release, and (3) duration of use for either transdermal fentanyl or oxycodone HCl controlled-release of at least 6 weeks.

Regulation (controlled) of Localization (release) of HCl

1) Confidence 0.22 Published 2003 Journal J Manag Care Pharm Section Body Doc Link 14613465 Disease Relevance 0.07 Pain Relevance 0

The inclusion criteria for the study were (1) diagnosis of chronic nonmalignant pain, (2) prescription for and current use of either transdermal fentanyl or oxycodone HCl controlled-release, and (3) duration of use for either transdermal fentanyl or oxycodone HCl controlled-release of at least 6 weeks.

Regulation (controlled) of Localization (release) of HCl

2) Confidence 0.22 Published 2003 Journal J Manag Care Pharm Section Body Doc Link 14613465 Disease Relevance 0.07 Pain Relevance 0

Our aim was to identify which cell types express TRPV1 in the human stomach in order to gain a better insight in the role of this receptor in the regulation of HCl secretion.

Regulation (regulation) of Localization (secretion) of HCl in stomach

3) Confidence 0.06 Published 2005 Journal Histochem. Cell Biol. Section Abstract Doc Link 16041554 Disease Relevance 0 Pain Relevance 0.26

The presumed TRPV1 mitochondrial location inside parietal cells is in favour of the existence of a local pathway of auto-regulation of HCl secretion.

Regulation (auto-regulation) of Localization (secretion) of HCl in parietal cells

4) Confidence 0.06 Published 2005 Journal Histochem. Cell Biol. Section Abstract Doc Link 16041554 Disease Relevance 0 Pain Relevance 0.14

Our aim was to identify which cell types express TRPV1 in the human stomach in order to gain a better insight in the role of this receptor in the regulation of HCl secretion.

Regulation (role) of Localization (secretion) of HCl in stomach

5) Confidence 0.06 Published 2005 Journal Histochem. Cell Biol. Section Abstract Doc Link 16041554 Disease Relevance 0 Pain Relevance 0.26

General Comments

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