INT114420

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Context Info
Confidence 0.54
First Reported 2003
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 67
Total Number 68
Disease Relevance 34.86
Pain Relevance 12.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
macrophage 3
neutrophil 3
lung 2
spinal cord 1
skeletal muscle 1
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 844 99.90 Very High Very High Very High
Kinase C 158 99.76 Very High Very High Very High
Inflammation 959 99.68 Very High Very High Very High
Inflammatory response 318 99.36 Very High Very High Very High
Spinal cord 2 98.96 Very High Very High Very High
Morphine 11 98.54 Very High Very High Very High
cytokine 395 98.36 Very High Very High Very High
Antinociceptive 2 98.14 Very High Very High Very High
Pain 37 97.96 Very High Very High Very High
antagonist 34 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 889 99.90 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 1080 99.74 Very High Very High Very High
INFLAMMATION 1296 99.68 Very High Very High Very High
Rhinitis 10 99.42 Very High Very High Very High
Apoptosis 168 99.40 Very High Very High Very High
Insulin Resistance 91 99.40 Very High Very High Very High
Malignant Neoplastic Disease 10 99.16 Very High Very High Very High
Stress 370 98.90 Very High Very High Very High
Disease 721 98.88 Very High Very High Very High
Pressure And Volume Under Development 275 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic DAMGO desensitization was heterologous in nature and significantly attenuated by blocking the activity of PI3K or mitogen-activated protein kinase (MAPK).
Negative_regulation (blocking) of PI3K
1) Confidence 0.54 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614088 Disease Relevance 0.09 Pain Relevance 0.39
Again, inhibition of PI3K or MAPK reduced desensitization of PPF.
Negative_regulation (inhibition) of PI3K
2) Confidence 0.54 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614088 Disease Relevance 0 Pain Relevance 0.25
This study provides new evidence showing that inactivation of the PI3K signaling pathway in the spinal cord may be involved in the expression of morphine withdrawal.
Negative_regulation (inactivation) of PI3K in spinal cord associated with withdrawal, morphine and spinal cord
3) Confidence 0.43 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16806705 Disease Relevance 0 Pain Relevance 0.86
2-adrenoceptors with yohimbine and by inhibition of PI3Ks with LY-294002.
Negative_regulation (inhibition) of PI3K
4) Confidence 0.41 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.31
Inhibition of peripheral PI3K signaling dose-dependently prevented and reversed pain behaviors and spinal Fos protein expression induced by intraplantar injection of ephrinB1-Fc.
Negative_regulation (Inhibition) of PI3K in spinal associated with pain
5) Confidence 0.41 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20170671 Disease Relevance 0.33 Pain Relevance 0.44
Unlike insulin, the effect of berberine on increasing glucose uptake was insensitive to wortmannin, an inhibitor of PI3K, and SB203580, an inhibitor of p38 MAPK [7].
Negative_regulation (inhibitor) of PI3K
6) Confidence 0.40 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.28 Pain Relevance 0
Wortmannin, a phosphoinositide-3 kinase (PI3K) inhibitor, selectively attenuated the effect of benidipine on the endothelial differentiation.
Negative_regulation (inhibitor) of PI3K
7) Confidence 0.38 Published 2006 Journal Hypertens. Res. Section Abstract Doc Link 17378377 Disease Relevance 0.13 Pain Relevance 0.07
The dose-response lines for antinociceptive effects of morphine were significantly shifted to the right following i.c.v. treatment with PI3K inhibitors.
Negative_regulation (inhibitors) of PI3K associated with antinociceptive and morphine
8) Confidence 0.35 Published 2004 Journal Neuroscience Section Abstract Doc Link 14980723 Disease Relevance 0.36 Pain Relevance 1.04
In response to HF diet stimulation insulin signal transduction was suppressed due to down-regulation of Pik3r1, Pik3r2, and Akt2 genes.
Negative_regulation (down) of Pik3r1
9) Confidence 0.30 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.22 Pain Relevance 0
The SNC80-induced neural differentiation was also inhibited by treatment with the protein kinase C (PKC) inhibitor, phosphatidylinositol 3-kinase (PI3K) inhibitor, mitogen-activated protein kinase kinase (MEK) inhibitor or Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor.
Negative_regulation (inhibitor) of PI3K in neural associated with kinase c
10) Confidence 0.29 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16696856 Disease Relevance 0.21 Pain Relevance 0.54
LPS resulted in a time-dependent activation of Akt, which was blocked by treatment with rolipram or PI3K and Akt inhibitors, and PI3K and Akt inhibitors also enhanced apoptosis and promoted neutrophil clearance.
Negative_regulation (inhibitors) of PI3K in neutrophil associated with apoptosis
11) Confidence 0.29 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.67 Pain Relevance 0.25
LPS resulted in a time-dependent activation of Akt, which was blocked by treatment with rolipram or PI3K and Akt inhibitors, and PI3K and Akt inhibitors also enhanced apoptosis and promoted neutrophil clearance.
Negative_regulation (inhibitors) of PI3K in neutrophil associated with apoptosis
12) Confidence 0.29 Published 2010 Journal J. Leukoc. Biol. Section Abstract Doc Link 20103769 Disease Relevance 0.73 Pain Relevance 0.31
U0126 (a MEK1/2 inhibitor) or LY294002 (a PI3K inhibitor) was added to ST2 and MC3T3-E1 cells, and was found to inhibit RANKL mRNA and RANKL protein expression in these cells.
Negative_regulation (inhibitor) of PI3K in MC3T3-E1
13) Confidence 0.28 Published 2007 Journal Mol. Cell. Biochem. Section Abstract Doc Link 17549607 Disease Relevance 0.33 Pain Relevance 0.04
The PI3K pathway is activated after allergen challenge in sensitized mice and expression of a dominant-negative PI3K subunit or use of PI3K inhibitors ameliorate the inflammatory response to allergen [4], [5], [6].
Negative_regulation (inhibitors) of PI3K associated with inflammatory response
14) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994819 Disease Relevance 0.62 Pain Relevance 0.15
We could also demonstrate that hippocampal cells that lack the octarepeat region showed reduced PI3K levels and decreased survival under stress conditions similar to PrPC knockout cells.
Negative_regulation (reduced) of PI3K associated with targeted disruption and stress
15) Confidence 0.27 Published 2007 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC1859984 Disease Relevance 0.66 Pain Relevance 0.05
Furthermore, we observed that the Akt phosphorylation induced by MES was suppressed in the presence of PI3K inhibitors, LY294002 and wortmannin (Fig. 8F; pAkt).
Negative_regulation (inhibitors) of PI3K
16) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.19 Pain Relevance 0
Downregulation of the translation regulatory signaling pathways via PI3K/Akt/mTOR in Ames mice provides evidence of the decreased protein synthesis, lack of growth, and, potentially, the decreased incidence of cancer in the face of increased food consumption (Sharp and Bartke 2005).
Negative_regulation (Downregulation) of PI3K in face associated with cancer
17) Confidence 0.26 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.73 Pain Relevance 0
Because insulin resistance is characterized by a marked reduction in insulin-stimulated PI3K-mediated activation of Akt, we asked whether MES could increase Akt phosphorylation and ameliorate insulin resistance.
Negative_regulation (reduction) of PI3K associated with insulin resistance
18) Confidence 0.26 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2603588 Disease Relevance 0.86 Pain Relevance 0
In addition, the reduction in PI3K and mTOR signaling and subsequent attenuation of anabolism may simulate a stressful situation and upregulate general defense and repair systems, which, in the long term, extend lifespan.
Negative_regulation (reduction) of PI3K associated with lifespan
19) Confidence 0.25 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.75 Pain Relevance 0
Fukaya et al. [18] reported that inhibition of Akt signaling by either the expression of a dominant-negative form of Akt in LM8 cells or the treatment of LM8 cells with LY294002, which is a potent PI3K inhibitor, decreases the secretion of MMP-2 and suppresses cell invasion and motility [18].
Negative_regulation (inhibitor) of PI3K
20) Confidence 0.25 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.50 Pain Relevance 0

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