INT114421

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.07
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
fat cells 3
mesenteric vein 2
neuronal 2
muscle 1
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 9 100.00 Very High Very High Very High
Kinase C 196 99.56 Very High Very High Very High
Clonidine 78 94.84 High High
opioid receptor 4 90.36 High High
Pain 3 88.68 High High
Enkephalin 1 82.60 Quite High
Central nervous system 14 81.32 Quite High
agonist 14 81.04 Quite High
Root ganglion neuron 1 76.00 Quite High
Opioid 5 75.00 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 145 99.64 Very High Very High Very High
Mycobacterial Infection 96 97.60 Very High Very High Very High
Disease 113 96.48 Very High Very High Very High
Obesity 100 93.32 High High
Infection 61 92.64 High High
Necrosis 59 91.40 High High
Pain 3 88.68 High High
Aging 8 88.44 High High
Targeted Disruption 113 84.16 Quite High
Adhesions 24 83.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous studies have shown that sustained activation of NGF/PI3K/Akt/NF-kappaB signaling is essential for NGF-induced dor gene expression during neuronal differentiation and that the epigenetic modifications at histone 3 lysine 9 temporally correlate with the dor gene transcription.
Positive_regulation (essential) of Positive_regulation (activation) of PI3K in neuronal associated with nerve growth factor
1) Confidence 0.49 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399742 Disease Relevance 0.09 Pain Relevance 0.52
These observations raise the possibility that the EFS and exogenous NE-induced activation of PI3Ks may be mediated by ?
Positive_regulation (induced) of Positive_regulation (activation) of PI3K
2) Confidence 0.49 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.34
These observations raise the possibility that the EFS and exogenous NE-induced activation of PI3Ks may be mediated by ?
Positive_regulation (mediated) of Positive_regulation (activation) of PI3K
3) Confidence 0.49 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.34
These results indicate that NE-elicited phosphorylation of Akt in mesenteric vein requires activation of PI3Ks.
Positive_regulation (requires) of Positive_regulation (activation) of PI3K in mesenteric vein
4) Confidence 0.49 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.30
Furthermore, upregulation of the PI3K-Akt pathway in mutant mice lacking phosphatase and tensin homolog, a lipid phosphatase counteracting PI3K, selectively enhanced chronic desensitization in a PI3K- and MAPK-dependent manner.
Positive_regulation (enhanced) of Positive_regulation (upregulation) of PI3K
5) Confidence 0.46 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614088 Disease Relevance 0.08 Pain Relevance 0.34
These results are consistent with a mechanism wherein EP2 activation of PKA, rather than EP4 activation of PI3K, mediates the protective effect of PGE2 on mitochondria of Mtb-infected M?.


Positive_regulation (activation) of Positive_regulation (activation) of PI3K associated with mycobacterial infection
6) Confidence 0.22 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.90 Pain Relevance 0
Furthermore, HDL inhibit thrombin-induced human endothelial TF expression through inhibition of RhoA and activation of PI3K but not Akt/eNOS (Viswambharan et al 2004).
Positive_regulation (induced) of Positive_regulation (activation) of PI3K associated with disorder of lipid metabolism
7) Confidence 0.16 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.19 Pain Relevance 0
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Positive_regulation (results) of Positive_regulation (activation) of PI3K
8) Confidence 0.15 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.99 Pain Relevance 0.04
Intriguingly, whereas many growth factors trigger the activation of PI3K, AKT, and PKC in many cell types, aspects of the c-Cbl–CAP pathway, including the tyrosine phosphorylation and the expression of CAP, seem to be unique to muscle and fat cells [144].
Positive_regulation (trigger) of Positive_regulation (activation) of PI3K in fat cells associated with kinase c and obesity
9) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.41 Pain Relevance 0.13
Intriguingly, whereas many growth factors trigger the activation of PI3K, AKT, and PKC in many cell types, aspects of the c-Cbl–CAP pathway, including the tyrosine phosphorylation and the expression of CAP, seem to be unique to muscle and fat cells [144].
Positive_regulation (trigger) of in muscle Positive_regulation (activation) of PI3K in fat cells associated with kinase c and obesity
10) Confidence 0.05 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.41 Pain Relevance 0.13

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