INT114432

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Context Info
Confidence 0.18
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1, Akt1) plasma membrane (Oprl1, Akt1) transport (Akt1)
aging (Akt1) enzyme binding (Akt1) carbohydrate metabolic process (Akt1)
Oprl1 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 2 99.96 Very High Very High Very High
Buprenorphine 14 99.60 Very High Very High Very High
agonist 3 96.88 Very High Very High Very High
orphanin 2 96.24 Very High Very High Very High
opioid receptor 7 95.52 Very High Very High Very High
Opioid 1 93.84 High High
antinociception 7 92.64 High High
Pain management 1 84.64 Quite High
opiate 1 83.52 Quite High
antagonist 3 81.52 Quite High
Disease Link Frequency Relevance Heat
Pain 1 84.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate that buprenorphine, but not morphine, activates mitogen-activated protein kinase and Akt via ORL-1 receptors.
ORL-1 Positive_regulation (activates) of Akt associated with morphine and buprenorphine
1) Confidence 0.18 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614092 Disease Relevance 0.08 Pain Relevance 2.20

General Comments

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