INT114433

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.50
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2rl1) plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
endothelial cells 2
knee joint 2
F2rl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spontaneous pain 1 99.98 Very High Very High Very High
Inflammation 26 99.64 Very High Very High Very High
allodynia 3 99.56 Very High Very High Very High
Hyperalgesia 5 99.36 Very High Very High Very High
agonist 11 94.16 High High
chemokine 1 91.60 High High
antagonist 3 79.28 Quite High
qutenza 4 77.68 Quite High
Angina 1 76.00 Quite High
cytokine 3 68.68 Quite High
Disease Link Frequency Relevance Heat
Pain 1 99.98 Very High Very High Very High
INFLAMMATION 20 99.64 Very High Very High Very High
Neuropathic Pain 3 99.56 Very High Very High Very High
Hyperalgesia 5 99.36 Very High Very High Very High
Pressure And Volume Under Development 4 94.64 High High
Nociception 3 94.08 High High
Cancer 2 83.76 Quite High
Necrosis 2 83.28 Quite High
Vasculitis 1 80.00 Quite High
Atherosclerosis 5 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proteinase-activated receptor-2 (PAR2) activation induces colonic inflammation by an unknown mechanism.
Positive_regulation (induces) of Positive_regulation (activation) of PAR2 associated with inflammation
1) Confidence 0.49 Published 2003 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 14614531 Disease Relevance 0.45 Pain Relevance 0.45
Proteinase-activated receptor-2 (PAR2) activation induces colonic inflammation by an unknown mechanism.
Positive_regulation (induces) of Positive_regulation (activation) of Proteinase-activated receptor-2 associated with inflammation
2) Confidence 0.49 Published 2003 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 14614531 Disease Relevance 0.45 Pain Relevance 0.45
These data provide evidence for a significant role of TRPV1 receptors in secondary mechanical hyperalgesia/allodynia and spontaneous pain induced by PAR-2 receptor activation in the knee joint.
Positive_regulation (induced) of Positive_regulation (activation) of PAR-2 receptor in knee joint associated with pain, hyperalgesia, allodynia and spontaneous pain
3) Confidence 0.45 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19683949 Disease Relevance 1.45 Pain Relevance 1.01
We showed that the LIGHT-mediated upregulation of PAR-2 in endothelial cells is mediated through the HVEM receptor, involving Jun N-terminal kinase signaling pathways.
Positive_regulation (mediated) of Positive_regulation (upregulation) of PAR-2 in endothelial cells
4) Confidence 0.21 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19023130 Disease Relevance 1.15 Pain Relevance 0.40

General Comments

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