INT114434

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.81
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Calcrl) endosome (Calcrl) signal transduction (Calcrl)
endoplasmic reticulum (Calcrl) plasma membrane (Calcrl) lysosome (Calcrl)
Anatomy Link Frequency
muscle 3
outflow 1
Tail 1
Calcrl (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 99.56 Very High Very High Very High
agonist 17 98.72 Very High Very High Very High
qutenza 8 98.54 Very High Very High Very High
Calcitonin gene-related peptide 6 98.04 Very High Very High Very High
substance P 4 97.18 Very High Very High Very High
antagonist 13 95.36 Very High Very High Very High
Neuropeptide 5 94.16 High High
Calcium channel 1 93.24 High High
metalloproteinase 5 84.92 Quite High
Hippocampus 4 83.16 Quite High
Disease Link Frequency Relevance Heat
Neurogenic Inflammation 2 99.56 Very High Very High Very High
Hypertension 15 98.88 Very High Very High Very High
Glaucoma 225 98.56 Very High Very High Very High
Ocular Hypertension 40 98.52 Very High Very High Very High
Colitis 3 98.08 Very High Very High Very High
INFLAMMATION 50 98.00 Very High Very High Very High
Targeted Disruption 17 97.76 Very High Very High Very High
Paralysis 10 97.68 Very High Very High Very High
Congenital Anomalies 5 97.40 Very High Very High Very High
Bronchial Hyperreactivity 2 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that overexpression of CALCRL can lead to increased sensitivity of the sphincter muscle to endogenous AM, thus causing chronic relaxation of the sphincter muscle and, as a consequence, obstruction of the aqueous outflow system.
Gene_expression (overexpression) of CALCRL in outflow
1) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773738 Disease Relevance 0.67 Pain Relevance 0.03
Taken together we expected that the degree of expression of CALCRL and the receptor activity of its product would affect the occurrence or development of angle closure glaucoma.
Gene_expression (expression) of CALCRL associated with glaucoma
2) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773738 Disease Relevance 0.73 Pain Relevance 0.05
However mice that overexpressed CALCRL in smooth muscle-containing tissues had increased CALCRL/RAMP2 (AM receptors) in the pupillary sphincter muscle, resulting in enhanced AM-induced sphincter muscle relaxation.
Gene_expression (overexpressed) of CALCRL in muscle
3) Confidence 0.68 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773738 Disease Relevance 0.49 Pain Relevance 0
Overexpression of calcitonin receptor-like receptor (CALCRL) in the pupillary sphincter muscle resulted in pupillary palsy and acutely and transiently elevated IOP in mice, mimicking the characteristic phenotype of acute PACG in humans.
Gene_expression (Overexpression) of calcitonin receptor-like receptor in muscle associated with glaucoma, ocular hypertension and paralysis
4) Confidence 0.60 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773738 Disease Relevance 1.25 Pain Relevance 0.04
Overexpression of calcitonin receptor-like receptor (CALCRL) in the pupillary sphincter muscle resulted in pupillary palsy and acutely and transiently elevated IOP in mice, mimicking the characteristic phenotype of acute PACG in humans.
Gene_expression (Overexpression) of CALCRL in muscle associated with glaucoma, ocular hypertension and paralysis
5) Confidence 0.60 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2773738 Disease Relevance 1.25 Pain Relevance 0.04
As an example, figure 2a and 2b demonstrate the selective expression of Calcrl and Gprc5b in BMM and TEPM, respectively.
Gene_expression (expression) of Calcrl
6) Confidence 0.58 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.17 Pain Relevance 0.09
Chrm4, Tail Clip Male Positional candidates on Chr 2) (Dussor et al. 2004) and calcitonin receptor-like genes or calcitonin gene-related peptides (e.g.
Gene_expression (genes) of receptor-like in Tail
7) Confidence 0.51 Published 2010 Journal Genes, Brain, and Behavior Section Body Doc Link PMC2855868 Disease Relevance 0.09 Pain Relevance 0.12
Immunohistochemistry demonstrated a differential expression of a marker for the type-1 CGRP receptor during the time course of PAR2-agonist-induced colitis, further suggesting a role for CGRP.
Gene_expression (expression) of type-1 CGRP receptor associated with colitis and agonist
8) Confidence 0.48 Published 2003 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 14614531 Disease Relevance 0.54 Pain Relevance 0.62
Those GPCRs that were highly expressed by BMM, but not TEPM, included Ebi2, Calcrl, Ccr2 and 5, Cxcr3, Cx3cr1 and Gpr84, whilst TEPM expressed much higher levels of Cxcr4, Gpr35, P2ry1, Ccr1, Cd97, Ccrl2 and Gprc5b (Table 2).
Neg (not) Gene_expression (expressed) of Calcrl
9) Confidence 0.45 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.19 Pain Relevance 0.10
Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive afferents induce neurogenic inflammation via NK(1), NK(2) and CGRP1 receptor activation.
Gene_expression (activation) of CGRP1 receptor associated with inflammation, qutenza, neurogenic inflammation, calcitonin gene-related peptide and substance p
10) Confidence 0.22 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17291600 Disease Relevance 0.43 Pain Relevance 0.75

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