INT114447

Context Info Confidence 0.00 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.72 Pain Relevance 0.43

cell differentiation (Camk1) signal transduction (Camk1) nucleocytoplasmic transport (Camk1) nucleus (Camk1) cell cycle (Camk1) cytoplasm (Camk1)

Anatomy Link Frequency L-2 2 Camk1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat tetrodotoxin 2 99.98 nMDA receptor 4 95.76 cerebral cortex 2 75.00

Disease Link Frequency Relevance Heat Convulsion 10 94.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Blocking transcription with actinomycin-D prevented activity-dependent changes in CaMKII-alpha and CaMKII-delta mRNA, but produced opposite effects on basal transcription, resulting in more stabilized CaMKII-alpha mRNA and less stabilized CaMKII-delta mRNA.

Negative_regulation (prevented) of Regulation (changes) of CaMKII-alpha

1) Confidence 0.00 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614906 Disease Relevance 0.35 Pain Relevance 0.21

Prior exposure to tetrodotoxin prevented the changes in CaMKII-alpha and CaMKII-delta mRNA regulation and this was mimicked by D-L-2-amino-5-phosphonovaleric acid, but not by 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline, suggesting that CaMKII-alpha and CaMKII-delta mRNA expression is regulated in an N-methyl-D-aspartate receptor-dependent manner.

Negative_regulation (prevented) of Regulation (regulation) of CaMKII-alpha in L-2 associated with tetrodotoxin and nmda receptor

2) Confidence 0.00 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614906 Disease Relevance 0.38 Pain Relevance 0.22

General Comments

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