INT114448

Context Info Confidence 0.01 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.52 Pain Relevance 0.30

cell differentiation (Camk1) signal transduction (Camk1) nucleocytoplasmic transport (Camk1) nucleus (Camk1) cell cycle (Camk1) cytoplasm (Camk1)

Anatomy Link Frequency L-2 2 Camk1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat nMDA receptor 4 99.72 tetrodotoxin 2 95.92 cerebral cortex 2 75.00

Disease Link Frequency Relevance Heat Convulsion 10 86.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Prior exposure to tetrodotoxin prevented the changes in CaMKII-alpha and CaMKII-delta mRNA regulation and this was mimicked by D-L-2-amino-5-phosphonovaleric acid, but not by 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline, suggesting that CaMKII-alpha and CaMKII-delta mRNA expression is regulated in an N-methyl-D-aspartate receptor-dependent manner.

Regulation (regulated) of Gene_expression (expression) of CaMKII-alpha in L-2 associated with tetrodotoxin and nmda receptor

1) Confidence 0.01 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614906 Disease Relevance 0.36 Pain Relevance 0.22

Alpha Calcium/calmodulin-dependent protein kinase type II (CaMKII-alpha) expression is regulated in an activity-dependent manner, but it is not known whether other CaMKII isoforms (beta, delta, and gamma) are similarly regulated.

Regulation (regulated) of Gene_expression (expression) of CaMKII-alpha

2) Confidence 0.01 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614906 Disease Relevance 0.16 Pain Relevance 0.07

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