INT11445

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Context Info
Confidence 0.31
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 3.29
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
chromaffin cells 2
subcutaneous adipose tissue 1
Slc12a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 24 100.00 Very High Very High Very High
Action potential 6 99.84 Very High Very High Very High
tetrodotoxin 11 99.28 Very High Very High Very High
Enkephalin 13 98.72 Very High Very High Very High
Neuropeptide 7 97.28 Very High Very High Very High
depression 6 96.64 Very High Very High Very High
repetitive firing 3 96.04 Very High Very High Very High
Calcium channel 5 96.00 Very High Very High Very High
ischemia 2 89.00 High High
anticonvulsant 1 85.20 High High
Disease Link Frequency Relevance Heat
Obesity 150 99.62 Very High Very High Very High
Depression 6 96.64 Very High Very High Very High
Anaerobic Bacterial Infections 1 94.88 High High
Increased Venous Pressure Under Development 7 93.32 High High
Cv Unclassified Under Development 1 89.00 High High
Hypoxia 1 88.48 High High
Disorder Of Lipid Metabolism 18 86.08 High High
Hypoglycemia 1 84.40 Quite High
Injury 1 83.68 Quite High
Brain Hemorrhage 1 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that phenytoin: (1) increases the threshold concentration of KCl to initiate the phenomenon; (2) decreases the velocity of propagation of spreading depression; (3) shortens considerably the duration of the slow potential, ionic (K+, Ca2+, Cl-), and volume changes of the extracellular compartment during spreading depression.
Positive_regulation (increases) of KCl associated with depression
1) Confidence 0.31 Published 1991 Journal Brain Res. Section Abstract Doc Link 1913149 Disease Relevance 1.19 Pain Relevance 0.47
A significant increase was already observed at 20 mM KCl and the maximal effect was obtained at 77 mM.
Positive_regulation (increase) of KCl
2) Confidence 0.19 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1560378 Disease Relevance 0 Pain Relevance 0.23
Exocytosis can be evoked by uniform electrical field pulses, which initiate tetrodotoxin-sensitive action potentials, or by elevated KCl. [3H]D-Aspartate is an authentic false transmitter in this preparation, judged by sensitivity of release to bafilomycin A1 and tetanus toxin.
Positive_regulation (elevated) of KCl associated with action potential, tetrodotoxin and anaerobic bacterial infections
3) Confidence 0.11 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300408 Disease Relevance 0.38 Pain Relevance 0.22
The DNA content, as an index of the number of cells, in the subcutaneous adipose tissue was significantly increased in the KCL group than in the control and acetic acid groups.


Positive_regulation (increased) of KCL in subcutaneous adipose tissue associated with obesity
4) Confidence 0.07 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3002919 Disease Relevance 0.71 Pain Relevance 0
The mechanisms by which an elevated KCl level and the K+-channel inhibitor 4-aminopyridine induce release of transmitter glutamate from guinea-pig cerebral cortical synaptosomes are contrasted.
Positive_regulation (elevated) of KCl associated with glutamate
5) Confidence 0.06 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2553862 Disease Relevance 0 Pain Relevance 0.24
Consistent with this, the 4-aminopyridine-induced net uptake of 45Ca2+ is much lower than that following an elevated KCl level. 4-Aminopyridine induced the Ca2+-dependent release of glutamate, although with somewhat slower kinetics than that for KCl.
Positive_regulation (elevated) of KCl associated with glutamate
6) Confidence 0.06 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2553862 Disease Relevance 0 Pain Relevance 0.59
KCL was provided by EGAO Co., Ltd.
Positive_regulation (provided) of KCL
7) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3002919 Disease Relevance 0.20 Pain Relevance 0.09
The rate of fatty acid excretion was significantly increased in the KCL group.
Positive_regulation (increased) of KCL
8) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC3002919 Disease Relevance 0.57 Pain Relevance 0
In contrast to KCl, glutamate release and the increase in [Ca2+]c with 4-aminopyridine were almost entirely blocked by tetrodotoxin, a result indicating repetitive firing of Na+ channels.
Positive_regulation (increase) of KCl associated with tetrodotoxin, glutamate and repetitive firing
9) Confidence 0.03 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2553862 Disease Relevance 0 Pain Relevance 0.62
An increase in KCl depolarizes the cells, potentially triggering action potential initiation, and opens voltage-gated calcium channels to increase secretion in a Ca++-dependent manner.
Positive_regulation (increase) of KCl associated with action potential and calcium channel
10) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2838897 Disease Relevance 0.18 Pain Relevance 0.37
In the absence of LA, K+ channel blockade increased the KCl-, but decreased the carbachol-evoked [Ca2+](i) transients.
Positive_regulation (increased) of KCl
11) Confidence 0.00 Published 2003 Journal Anesthesiology Section Body Doc Link 12717135 Disease Relevance 0 Pain Relevance 0
We show here that the increase of enkephalin mRNA and peptide after depolarization of chromaffin cells with KCl or activation of adenylate cyclase with forskolin is preceded by an increase in enkephalin gene transcription.
Positive_regulation (activation) of KCl in chromaffin cells associated with enkephalin
12) Confidence 0.00 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8396715 Disease Relevance 0.06 Pain Relevance 0.69
Proenkephalin (PEnk) gene activation after depolarization of chromaffin cells with 40 mM KCl was blocked by the voltage-sensitive calcium-channel blocker methoxyverapamil (D600) (30 microM) and by calcineurin inhibition with 100 nM cyclosporin A or ascomycin but not by inhibiting new protein synthesis with 0.5 microg/ml cycloheximide.
Positive_regulation (activation) of KCl in chromaffin cells
13) Confidence 0.00 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14645681 Disease Relevance 0 Pain Relevance 0.08

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