INT114450

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Context Info
Confidence 0.03
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.17
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Camk1) signal transduction (Camk1) nucleocytoplasmic transport (Camk1)
nucleus (Camk1) cell cycle (Camk1) cytoplasm (Camk1)
Anatomy Link Frequency
L-2 1
Camk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 10 99.20 Very High Very High Very High
tetrodotoxin 3 95.92 Very High Very High Very High
antagonist 1 83.72 Quite High
cerebral cortex 3 75.00 Quite High
Inflammation 11 71.80 Quite High
long-term potentiation 2 52.68 Quite High
Pyramidal cell 24 11.40 Low Low
Hippocampus 17 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Cannabinoid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 33 99.76 Very High Very High Very High
Status Epilepticus 57 98.56 Very High Very High Very High
Apoptosis 8 81.32 Quite High
INFLAMMATION 12 71.80 Quite High
Gliosis 4 71.24 Quite High
Epilepsy 16 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of calmodulin 1 (CaM1) and calmodulin 2 (CaM2) were down-regulated (?
Gene_expression (expression) of CaM1
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.32 Pain Relevance 0.10
Prior exposure to tetrodotoxin prevented the changes in CaMKII-alpha and CaMKII-delta mRNA regulation and this was mimicked by D-L-2-amino-5-phosphonovaleric acid, but not by 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline, suggesting that CaMKII-alpha and CaMKII-delta mRNA expression is regulated in an N-methyl-D-aspartate receptor-dependent manner.
Gene_expression (expression) of CaMKII-alpha in L-2 associated with tetrodotoxin and nmda receptor
2) Confidence 0.01 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614906 Disease Relevance 0.36 Pain Relevance 0.22
Alpha Calcium/calmodulin-dependent protein kinase type II (CaMKII-alpha) expression is regulated in an activity-dependent manner, but it is not known whether other CaMKII isoforms (beta, delta, and gamma) are similarly regulated.
Gene_expression (expression) of CaMKII-alpha
3) Confidence 0.01 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614906 Disease Relevance 0.16 Pain Relevance 0.07
Following seizure induction, CaMKII-alpha expression was downregulated and CaMKII-delta expression upregulated while CaMKII-beta and CaMKII-gamma expression was unaffected.
Gene_expression (expression) of CaMKII-alpha associated with convulsion
4) Confidence 0.01 Published 2003 Journal Neuroscience Section Abstract Doc Link 14614906 Disease Relevance 0.33 Pain Relevance 0.13

General Comments

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