INT11447

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 3.12
Pain Relevance 4.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DECR1) small molecule metabolic process (DECR1) nucleolus (DECR1)
nucleus (DECR1) cytoplasm (DECR1)
Anatomy Link Frequency
neutrophil 2
coronary artery 1
aorta 1
liver 1
Islets of Langerhans 1
DECR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 13 99.56 Very High Very High Very High
cINOD 36 99.48 Very High Very High Very High
Chronic pancreatitis 6 98.00 Very High Very High Very High
lidocaine 15 97.68 Very High Very High Very High
Morphine 4 97.66 Very High Very High Very High
diclofenac 6 96.44 Very High Very High Very High
Kinase C 15 96.16 Very High Very High Very High
alcohol 1 92.52 High High
Analgesic 2 75.00 Quite High
transdermal 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress 37 99.92 Very High Very High Very High
INFLAMMATION 35 99.32 Very High Very High Very High
Cadaver 4 99.04 Very High Very High Very High
Diabetes Mellitus 83 98.56 Very High Very High Very High
Pancreatitis 6 98.00 Very High Very High Very High
Pancreatic Cancer 6 96.56 Very High Very High Very High
Hypertension 13 90.36 High High
Hyperglycemia 38 88.04 High High
Avian Sarcoma 1 82.48 Quite High
Respiratory Syncytial Virus 1 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lidocaine also inhibited the phosphorylation of 47 kDa neutrophil cytoplasmic protein, a phosphorylated protein required for activation of NADPH oxidase.
Positive_regulation (activation) of NADPH in neutrophil associated with lidocaine
1) Confidence 0.67 Published 1992 Journal Masui Section Abstract Doc Link 1560576 Disease Relevance 0 Pain Relevance 0.71
Islets of Langerhans showed high levels of P-450 IA2 in the donor group, with clear induction of P-450 IIIA1 and NADPH cytochrome P-450 oxidoreductase in patients with chronic pancreatitis but not in the pancreatic cancer group.
Neg (not) Spec (clear) Positive_regulation (induction) of NADPH in Islets of Langerhans associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.67 Published 1993 Journal J. Pathol. Section Abstract Doc Link 8501544 Disease Relevance 0.92 Pain Relevance 0.46
The up-regulation of NADPH oxidases by NSAIDs was associated with increased superoxide content in aorta and heart, which could be prevented by the NADPH oxidase inhibitor apocynin.
Positive_regulation (up-regulation) of NADPH in aorta associated with cinod
3) Confidence 0.49 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.32 Pain Relevance 0.75
Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases.
Positive_regulation (up-regulating) of NADPH associated with stress, inflammation, cinod and cox2
4) Confidence 0.49 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 18550689 Disease Relevance 0.38 Pain Relevance 0.86
CONCLUSIONS: ROS generated by p22(phox)-based NADH/NADPH oxidase likely mediate the oxidative modification of LDL and might play a major role in pathogenesis of atherosclerotic coronary artery disease.


Positive_regulation (-based) of NADPH in coronary artery
5) Confidence 0.49 Published 2002 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 12426213 Disease Relevance 0 Pain Relevance 0
This cell line expressed cytochrome b5 (58 +/- 12 pmol/mg microsomal protein vs 528 +/- 80 pmol/mg in microsomal human liver) and a high level of NADPH: cytochrome P450 reductase (140 +/- 20 nmol.min-1.mg microsomal protein-1 vs 68 +/- 48 nmol.min-1.mg-1 in microsomal human liver).
Positive_regulation (level) of NADPH in liver
6) Confidence 0.49 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.16 Pain Relevance 0.05
No significant metabolic degradation of morphine, fentnayl, and sufentanil was observed in either fresh human cadaver skin or hairless mouse skin homogenates in the presence of NADPH cofactor, suggesting a low monooxygenase enzyme presence in skin.
Positive_regulation (presence) of NADPH in skin associated with cadaver and morphine
7) Confidence 0.49 Published 1994 Journal J Pharm Sci Section Abstract Doc Link 7891301 Disease Relevance 0.31 Pain Relevance 0.48
Lidocaine also inhibited the phosphorylation of 47 kDa neutrophil cytosplasmic protein, a phosphorylated protein required for NADPH oxidase activation.
Positive_regulation (activation) of NADPH in neutrophil associated with lidocaine
8) Confidence 0.45 Published 1990 Journal Physiol Chem Phys Med NMR Section Abstract Doc Link 1966297 Disease Relevance 0 Pain Relevance 0.84
The up-regulation of NADPH oxidases by NSAIDs was associated with increased superoxide content in aorta and heart, which could be prevented by the NADPH oxidase inhibitor apocynin.
Positive_regulation (up-regulation) of NADPH in heart associated with cinod
9) Confidence 0.17 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.32 Pain Relevance 0.75
In addition to mitochondrial uncoupling there are other mechanisms that can contribute to superoxide production in diabetes, namely, uncoupling of eNOS, increased peroxidation and glycoxidation, activation of NADPH oxidases, decreased clearance of superoxide, and impaired antioxidant status [61].
Positive_regulation (activation) of NADPH associated with diabetes mellitus
10) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.71 Pain Relevance 0.04

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