INT114475

Context Info Confidence 0.36 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.50 Pain Relevance 0.42

peptidase activity (Bap1) nucleolus (Bap1) nucleus (Bap1) intracellular (Bap1) cytoplasm (Bap1)

Anatomy Link Frequency microglial cells 2 Bap1 (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 1 99.32 cINOD 3 95.48 aspirin 1 94.36 Inflammation 1 75.00 Inflammatory response 1 74.64

Disease Link Frequency Relevance Heat Drug Induced Neurotoxicity 4 97.44 INFLAMMATION 3 94.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Marked reduction of dopamine transporter-positive signals and accumulation of microglial cells in the striatum after METH injections (4 mg/kg x4, i.p. with 2 h-interval) were significantly and dose-dependently attenuated by four injections of ketoprofen (2 or 5 mg/kg x4, s.c.) given 30 min prior to each METH injection, but not by either a low or high dose of aspirin.

Negative_regulation (attenuated) of Positive_regulation (accumulation) of x4 in microglial cells associated with aspirin and dopamine

1) Confidence 0.36 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14615038 Disease Relevance 0.50 Pain Relevance 0.42

General Comments

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