INT114490

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 11.35
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PDLIM7) cytoplasm (PDLIM7)
Anatomy Link Frequency
teeth 5
stroma 1
smooth muscle 1
endothelial cells 1
odontoblasts 1
PDLIM7 (Homo sapiens)
Pain Link Frequency Relevance Heat
pulpitis 14 99.04 Very High Very High Very High
Pain 14 90.60 High High
metalloproteinase 16 81.56 Quite High
ischemia 2 77.04 Quite High
Facet joint 57 5.00 Very Low Very Low Very Low
imagery 43 5.00 Very Low Very Low Very Low
cytokine 17 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Nicotine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epstein-barr Virus 265 100.00 Very High Very High Very High
Nasopharynx Cancer 580 99.84 Very High Very High Very High
Cancer 209 99.76 Very High Very High Very High
Apoptosis 47 99.60 Very High Very High Very High
Calcification 17 99.36 Very High Very High Very High
Pulpitis 14 99.04 Very High Very High Very High
Hodgkin's Disease 219 98.68 Very High Very High Very High
Lymphatic System Cancer 9 97.52 Very High Very High Very High
Osteoporosis 7 97.40 Very High Very High Very High
Autoimmune Hepatitis 1 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LMP-1 expression was determined by immunohistochemistry in all of the samples including 12 healthy teeth, 10 teeth with caries, 12 teeth with pulpitis, and 4 teeth with pulp calcification.
Gene_expression (expression) of LMP-1 in teeth associated with calcification and pulpitis
1) Confidence 0.78 Published 2008 Journal J Endod Section Abstract Doc Link 18215669 Disease Relevance 0.39 Pain Relevance 0.16
We found that LMP-1 was expressed primarily in predentin, odontoblasts, and endothelial cells of the blood vessels of healthy teeth.
Gene_expression (expressed) of LMP-1 in odontoblasts
2) Confidence 0.78 Published 2008 Journal J Endod Section Abstract Doc Link 18215669 Disease Relevance 0.43 Pain Relevance 0.18
The aim of this study was to detect the expression of LMP-1 in normal healthy human teeth and human teeth with various pathologic conditions.
Gene_expression (expression) of LMP-1 in teeth
3) Confidence 0.78 Published 2008 Journal J Endod Section Abstract Doc Link 18215669 Disease Relevance 0.31 Pain Relevance 0.14
Furthermore, we found LMP-1 expression on the surface of the pulp stone or in the residual predentin of teeth with pulp calcification.
Gene_expression (expression) of LMP-1 in teeth associated with calcification
4) Confidence 0.78 Published 2008 Journal J Endod Section Abstract Doc Link 18215669 Disease Relevance 0.44 Pain Relevance 0.18
However, the expression and distribution of LMP-1 in human teeth are largely unknown.
Gene_expression (expression) of LMP-1 in teeth
5) Confidence 0.78 Published 2008 Journal J Endod Section Abstract Doc Link 18215669 Disease Relevance 0.24 Pain Relevance 0.07
In addition, LMP-1 expression was also found in unmineralized reparative dentin, odontoblast-like cells, and pulp fibroblasts in teeth with caries and pulpitis.
Gene_expression (expression) of LMP-1 in teeth associated with pulpitis
6) Confidence 0.78 Published 2008 Journal J Endod Section Abstract Doc Link 18215669 Disease Relevance 0.44 Pain Relevance 0.19
Tumor cells were positive for CD 10, CD 20, CD 30, and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) and early region RNA (EBER).
Gene_expression (positive) of LMP-1 associated with cancer and epstein-barr virus
7) Confidence 0.63 Published 2003 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 14615832 Disease Relevance 1.12 Pain Relevance 0.17
Preclinical studies demonstrated that As2O3 could inhibit LMP-1 expression, dictate apoptosis and alterations of cell cycle distribution and growth retardation.
Gene_expression (expression) of LMP-1 associated with apoptosis
8) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 0.80 Pain Relevance 0
Pilot study of LMP-1 and CD99 expressions in NPC suggested that the LMP-1 induced down-regulation of the CD99 pathway was important in nasopharyngeal carcinogenesis, and that the expression of CD99 in lymphoid stroma might regulate immune response to NPC [80].
Gene_expression (expressions) of LMP-1 in stroma associated with nasopharynx cancer
9) Confidence 0.37 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 0.96 Pain Relevance 0.03
LMP-1 were reduced in this process and seemed to enhance anti-metastatic activity of As2O3 [83].
Gene_expression (reduced) of LMP-1
10) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.07 Pain Relevance 0
The nasopharyngeal swab coupled with PCR based EBV LMP-1 and EBNA detection could serve as a good supplement to pathological diagnosis of NPC [85].
Gene_expression (detection) of LMP-1 associated with nasopharynx cancer and epstein-barr virus
11) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.57 Pain Relevance 0
We found that LMP-1 was expressed primarily in predentin, odontoblasts, and endothelial cells of the blood vessels of healthy teeth.
Gene_expression (expressed) of LMP-1 in endothelial cells
12) Confidence 0.26 Published 2008 Journal J Endod Section Abstract Doc Link 18215669 Disease Relevance 0.43 Pain Relevance 0.18
EBV-positive HRS cells express EBNA1, key for viral genome replication, as well as LMP1 and LMP2a which mimic CD40 receptors and BCRs, respectively [47, 48].
Gene_expression (express) of LMP1 associated with epstein-barr virus
13) Confidence 0.22 Published 2011 Journal Advances in Hematology Section Body Doc Link PMC2994062 Disease Relevance 2.34 Pain Relevance 0
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Gene_expression (overexpression) of LIM mineralization protein 1
14) Confidence 0.15 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.09 Pain Relevance 0.04
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Gene_expression (overexpression) of LMP-1
15) Confidence 0.15 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.09 Pain Relevance 0.04
Yoon et al. reported that overexpression of LIM mineralization protein 1 (LMP-1),72 an intercellular protein, using an adenoviral vector (AdLMP-1) in rat IVD cells resulted in an increase of BMP-2 and BMP-7 gene expression and PG synthesis.73 BMP-2 and BMP-7 protein levels increased by two- to threefold.
Gene_expression (overexpression) of AdLMP-1
16) Confidence 0.10 Published 2006 Journal J Orthop Sci Section Body Doc Link PMC2778630 Disease Relevance 0.09 Pain Relevance 0.04
The neoplastic cells were negative for CD43, ALK, CD30, EMA, smooth muscle actin, cytokeratin, desmin, myogenin, TTF1, CD99, CD1a, LMP-1, CD117, HMB45, and Mart-1/Melan A.
Gene_expression (negative) of LMP-1 in smooth muscle
17) Confidence 0.04 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 0.54 Pain Relevance 0

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