INT114495

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.64
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCD) cytoskeleton (SGCD) cytoskeleton organization (SGCD)
cytoplasm (SGCD)
Anatomy Link Frequency
hepatocytes 1
muscle 1
skeletal muscle 1
SGCD (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 22 99.08 Very High Very High Very High
fibrosis 18 94.80 High High
member 8 2 91.52 High High
cINOD 2 78.16 Quite High
chemokine 2 35.48 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiomyopathy 78 99.56 Very High Very High Very High
Sprains And Strains 36 99.34 Very High Very High Very High
Fibrosis 60 94.80 High High
Muscular Dystrophy 78 91.32 High High
Dilated Cardiomyopathy 18 91.12 High High
Lifespan 54 90.00 High High
Skeletal Muscle Toxicity 6 89.60 High High
Disease 38 85.72 High High
Myocardial Infarction 24 85.72 High High
Hypertrophy 6 84.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggested that the four SNPs identified in this study were located within LD blocks that were part of the KCNMA1, SGCD, AKAP6, and PRKG1 genes and that did not extend beyond the gene boundaries.
Gene_expression (part) of SGCD
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0 Pain Relevance 0
0.02) of delta sarcoglycan (SGCD) at 5q33, SNP rs10508958 (p?
Gene_expression (at) of SGCD
2) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0 Pain Relevance 0.09
When diclofenac (100 microM) was incubated with hepatocytes, D-SG was detected in both rat and human incubation extracts by a sensitive LC-MS/MS technique.
Gene_expression (detected) of D-SG in hepatocytes associated with diclofenac
3) Confidence 0.44 Published 2003 Journal Chem. Res. Toxicol. Section Abstract Doc Link 14615966 Disease Relevance 0.08 Pain Relevance 0.40
Co-incubation of diclofenac (50 microM) with (-)-borneol (400 microM), an inhibitor of glucuronidation, led to a 94% decrease in D-1-O-G formation, although no significant decrease in D-SG production was observed.
Gene_expression (production) of D-SG associated with diclofenac
4) Confidence 0.44 Published 2003 Journal Chem. Res. Toxicol. Section Abstract Doc Link 14615966 Disease Relevance 0.05 Pain Relevance 0.44
This suggests that the double treatment could maintain a longer expression of delta-sarcoglycan.
Gene_expression (expression) of delta-sarcoglycan
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.30 Pain Relevance 0
We hypothesized that, after the first neonatal injection, the degeneration of muscle to fibrocalcific/fibroadipous tissue was prevented, thus a late injection with a different serotype could result in a transduction of the surviving muscle and boost the expression of the delta-sarcoglycan.
Gene_expression (expression) of delta-sarcoglycan in muscle
6) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.18 Pain Relevance 0
Body-wide restoration of delta-SG expression was associated with functional reconstitution of the sarcoglycan complex and with significant lowering of centralized nuclei and fibrosis in skeletal muscle.
Gene_expression (expression) of delta-SG in skeletal muscle associated with fibrosis
7) Confidence 0.20 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2660610 Disease Relevance 0.86 Pain Relevance 0.05
BIO14.6 hamsters having less than 70% of fibers expressing delta-sarcoglycan developed cardiomyopathy, even if the total amount of protein measured by western blot analysis was in the normal range or 3–4-fold above the normal range.
Gene_expression (expressing) of delta-sarcoglycan associated with cardiomyopathy
8) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.59 Pain Relevance 0
All strains carry the same homozygous 24-kb deletion of the delta-sarcoglycan (?
Gene_expression (deletion) of delta-sarcoglycan associated with sprains and strains
9) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 1.42 Pain Relevance 0
We observed that the delta-sarcoglycan expression was faint in the 7w 2/1 hamsters (not shown).
Gene_expression (expression) of delta-sarcoglycan
10) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660610 Disease Relevance 0.17 Pain Relevance 0

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