INT114498

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.82
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (MCPH1) intracellular (MCPH1) microtubule organizing center (MCPH1)
cytoplasm (MCPH1)
Anatomy Link Frequency
basement membranes 1
skin 1
body 1
MCPH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 27 99.46 Very High Very High Very High
Serotonin 10 99.06 Very High Very High Very High
metalloproteinase 30 97.90 Very High Very High Very High
sSRI 2 89.24 High High
fluoxetine 6 81.20 Quite High
Inflammation 13 76.16 Quite High
anesthesia 4 10.00 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 91 100.00 Very High Very High Very High
Pulmonary Hypertension 405 99.96 Very High Very High Very High
Hypoxia 17 99.76 Very High Very High Very High
Body Weight 15 98.32 Very High Very High Very High
Malignant Neoplastic Disease 22 95.40 Very High Very High Very High
Death 7 93.44 High High
Hypertrophy 78 93.32 High High
Skin Cancer 15 89.36 High High
Adhesions 55 87.20 High High
Anaphylaxis 13 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fine needle aspirations of MCT are usually rich in cells as these exfoliate easily and cytology is usually sufficient for a diagnosis of MCT.
Positive_regulation (sufficient) of MCT associated with cancer
1) Confidence 0.43 Published 2010 Journal Acta Vet Scand Section Body Doc Link PMC2823750 Disease Relevance 1.82 Pain Relevance 0
An allergic cause is more likely if there are associated features of anaphylaxis (skin changes, hypotension, angioedema) or elevated MCT.
Positive_regulation (elevated) of MCT in skin
2) Confidence 0.17 Published 2009 Journal Acta Anaesthesiol Scand Section Body Doc Link 19572931 Disease Relevance 0 Pain Relevance 0
Two patients showed elevated MCT, while specific IgE against the drugs tested was not detected.
Positive_regulation (elevated) of MCT
3) Confidence 0.15 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 14616317 Disease Relevance 0.07 Pain Relevance 0
Three patients tested negative to both MCT and specific IgE.
Positive_regulation (negative) of MCT
4) Confidence 0.11 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 14616317 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: Fifteen out of 18 sera tested positive for MCT and/or specific IgE against neuromuscular blocking drugs (NMBDs).
Positive_regulation (positive) of MCT
5) Confidence 0.11 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 14616317 Disease Relevance 0.06 Pain Relevance 0
RESULTS: Ten patients had elevated MCT levels and specific IgE against ammonium ion, morphine and (with the exception of patient nos 3, 9 and 10) suxamethonium.
Positive_regulation (elevated) of MCT
6) Confidence 0.10 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 14616317 Disease Relevance 0.09 Pain Relevance 0
Inhalation of tolafentrine, a combined PDE3/4 inhibitor, reversed PAH that occurred in response to MCT in rats.
Positive_regulation (response) of MCT associated with pulmonary hypertension
7) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.61 Pain Relevance 0
A serotonin receptor antagonist, MCI-9042, attenuated the development of MCT-induced PAH, suggesting a pivotal role of serotonin in the development of PAH induced by MCT [24].
Positive_regulation (development) of MCT-induced associated with pulmonary hypertension, antagonist and serotonin
8) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.09 Pain Relevance 0.60
No significant changes in systemic arterial pressure occurred in animals undergoing long-term tolafentrine inhalation (n = 8), while cardiac output was significantly increased in the MCT[42d]/Tola group.(42.1 ± 5.1 ml/min/100 g body weight; p < 0.05 versus MCT[42d]).
Positive_regulation (increased) of MCT in body associated with body weight
9) Confidence 0.02 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.63 Pain Relevance 0
In the present study, we demonstrate that daily repetitive tolafentrine inhalation significantly improved pulmonary hemodynamics and reversed structural and molecular changes underlying MCT induced PAH in rats.
Positive_regulation (underlying) of MCT associated with pulmonary hypertension
10) Confidence 0.02 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.73 Pain Relevance 0.04
Of the MMPs, expression of MMP 2 and MMP 9 in particular, which degrade type IV collagen of basement membranes, are increased in the pulmonary vascular bed, during both monocrotaline (MCT) and hypoxia-induced experimental PAH [5].
Positive_regulation (increased) of MCT in basement membranes associated with pulmonary hypertension, hypoxia and metalloproteinase
11) Confidence 0.02 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.66 Pain Relevance 0.27

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