INT114499

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 38
Total Number 38
Disease Relevance 26.68
Pain Relevance 4.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (MCPH1) intracellular (MCPH1) microtubule organizing center (MCPH1)
cytoplasm (MCPH1)
Anatomy Link Frequency
pulmonary artery 4
brain 2
colon 1
bone marrow 1
fibroblasts 1
MCPH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 23 99.72 Very High Very High Very High
Gabapentin 20 99.66 Very High Very High Very High
antagonist 276 99.60 Very High Very High Very High
Pain 1 98.88 Very High Very High Very High
Bioavailability 58 98.70 Very High Very High Very High
fluoxetine 69 98.48 Very High Very High Very High
corticosteroid 18 96.84 Very High Very High Very High
Potency 9 96.80 Very High Very High Very High
Serotonin 115 94.56 High High
Inflammation 122 93.04 High High
Disease Link Frequency Relevance Heat
Cancer 334 100.00 Very High Very High Very High
Pulmonary Hypertension 3450 99.96 Very High Very High Very High
Colon Cancer 16 99.84 Very High Very High Very High
Hypertrophy 828 99.64 Very High Very High Very High
Cold Sores 36 99.38 Very High Very High Very High
Hypoxia 165 99.32 Very High Very High Very High
Histiocytoma 12 99.28 Very High Very High Very High
Syndrome 10 99.28 Very High Very High Very High
Pain 1 98.88 Very High Very High Very High
Adhesions 48 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amplification of MCPH1 gene
Gene_expression (gene) of MCPH1
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0
Unfortunately, such methods cannot be used in the present case due to extract depletion, but, however, the most plausible hypothesis supported by all our findings is that the MLS individual was homozygous for the ancestral, non-D, microcephalin allele.
Gene_expression (allele) of microcephalin
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0
Of the graded cases, grade I MCT were excised in 11 cases (64.7%, CI: 42.0-87.4, of grade I cases), grade II in 25 cases (96.2%, CI: 88.8-100, of grade II cases) and grade III in 2 cases (25%, CII 0-55.0, of grade III cases).
Gene_expression (excised) of MCT in CII associated with cancer
3) Confidence 0.57 Published 2010 Journal Acta Vet Scand Section Body Doc Link PMC2823750 Disease Relevance 0.86 Pain Relevance 0.08
Thirteen of these cases were diagnosed as MCT and 5 cases were histiocytomas.
Gene_expression (diagnosed) of MCT associated with histiocytoma and cancer
4) Confidence 0.57 Published 2010 Journal Acta Vet Scand Section Body Doc Link PMC2823750 Disease Relevance 1.57 Pain Relevance 0.10
Prediction of outcome and treatment planning should be based on a panel of prognostic factors, rather than on a single prognostic factor since no such has proven superior to predict MCT prognosis alone [9,10].
Gene_expression (prognosis) of MCT in superior associated with cancer
5) Confidence 0.57 Published 2010 Journal Acta Vet Scand Section Body Doc Link PMC2823750 Disease Relevance 1.58 Pain Relevance 0
The MCT patch is hypothesized to produce stimuli that promote tissue healing by facilitating physiologic currents.
Gene_expression (produce) of MCT
6) Confidence 0.57 Published 2009 Journal Clin J Pain Section Abstract Doc Link 19542797 Disease Relevance 0.27 Pain Relevance 0.26
It's reported that microcephalin/MCPH1 is one of the causative genes responsible for the autosomal recessive disorder primary microcephaly.
Gene_expression (one) of MCPH1 associated with microcephaly
7) Confidence 0.48 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.68 Pain Relevance 0
MCT expression has been demonstrated along the length of the intestine with MCT1 being the predominant isoform (19).
Gene_expression (expression) of MCT in intestine
8) Confidence 0.22 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.04
Tissue localization of MCT expression suggests the potential for a large impact on the oral absorption, brain uptake and renal clearance of MCT substrates.
Gene_expression (expression) of MCT in brain
9) Confidence 0.20 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.12
In vivo studies on XP13512 demonstrated increased oral absorption and bioavailability in rats and monkeys when compared to gabapentin suggesting that exploitation of MCT-mediated uptake may provide a novel strategy for improving intestinal drug absorption (39).
Gene_expression (exploitation) of MCT associated with gabapentin and bioavailability
10) Confidence 0.19 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.32
Further studies need to be conducted to determine the influence of brain MCT expression on the overall disposition of MCT substrates and the potential therapeutic implications.


Gene_expression (expression) of MCT in brain
11) Confidence 0.17 Published 2008 Journal AAPS J Section Body Doc Link PMC2574616 Disease Relevance 0 Pain Relevance 0.20
RESULTS: Ten patients had elevated MCT levels and specific IgE against ammonium ion, morphine and (with the exception of patient nos 3, 9 and 10) suxamethonium.
Gene_expression (levels) of MCT
12) Confidence 0.14 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 14616317 Disease Relevance 0.09 Pain Relevance 0
Several major differences exist between MCT and LCT in respect with their in vivo fate, such as lipolytic products, differences in the modulation on gastric emptying (Hunt and Knox 1968) and the contraction of the gallbladder in humans (Ladas et al 1984).
Gene_expression (exist) of MCT
13) Confidence 0.10 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2374933 Disease Relevance 0 Pain Relevance 0.18
There has been interest in substituting MCT for some of the LCT.
Gene_expression (some) of MCT
14) Confidence 0.10 Published 1999 Journal Crit Care Section Body Doc Link PMC137235 Disease Relevance 0.55 Pain Relevance 0.04
In MC38/HSV1-Tk murine colon cancer cells, MCT had an IC5 of 2.9??
Gene_expression (had) of MCT in colon associated with cold sores and colon cancer
15) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 1.00 Pain Relevance 0
Four weeks after a single injection of MCT in rats, the animals displayed nearly threefold elevated pulmonary artery pressure and vascular resistance values, with a concomitant decline in central venous oxygen saturation and arterial oxygenation.
Gene_expression (injection) of MCT in pulmonary artery
16) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.81 Pain Relevance 0.03
Antibody therapy started together with MCT administration did not prevent development of pulmonary hypertension, but RV peak systolic pressure was significantly lower than observed in rats treated with MCT only.

(10) One day after MCT administration (60?

Gene_expression (administration) of MCT associated with pulmonary hypertension
17) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.93 Pain Relevance 0.11
Intratracheal transfer of the human prostacyclin synthase (PGIS) gene to rats with MCT-induced PAH augmented pulmonary prostacyclin synthesis, ameliorated MCT-induced PAH, and improved survival in MCT rats [56].
Gene_expression (transfer) of MCT-induced associated with pulmonary hypertension
18) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.76 Pain Relevance 0.04
The antagonism of the ETA receptor was shown to be essential for the protection from MCT-induced PAH, irrespective of the presence of the ETB receptors, although a protective role of ETB receptor-mediated action in the pathogenesis of this disease model could not be ruled out [18].
Gene_expression (protection) of MCT-induced associated with pulmonary hypertension and disease
19) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.87 Pain Relevance 0.15
Furthermore, a selective serotonin reuptake inhibitor, sertraline, protects against MCT-induced PAH by decreasing pulmonary artery pressure, RV hypertrophy index, and pulmonary artery remodeling, probably related to a reduction in serotonin transporter mRNA [23].
Gene_expression (protects) of MCT-induced in pulmonary artery associated with hypertrophy, pulmonary hypertension, serotonin and ssri
20) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 1.14 Pain Relevance 0.66

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