INT114504

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.77
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Scd1) endoplasmic reticulum (Scd1) lipid metabolic process (Scd1)
Anatomy Link Frequency
plasma 2
liver 2
neurons 2
hepatocyte 1
trabecular bone 1
Scd1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 7 98.76 Very High Very High Very High
substance P 6 98.14 Very High Very High Very High
primary afferent fibers 2 98.08 Very High Very High Very High
qutenza 2 94.72 High High
cytokine 8 93.32 High High
Kinase C 8 91.76 High High
Pain score 1 81.20 Quite High
Inflammation 41 77.76 Quite High
imagery 1 50.72 Quite High
Peripheral nerve injury 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 46 100.00 Very High Very High Very High
Apoptosis 38 99.24 Very High Very High Very High
Insulin Resistance 50 97.96 Very High Very High Very High
Age-related Macular Degeneration 9 97.60 Very High Very High Very High
Adhesions 15 94.72 High High
Anaerobic Bacterial Infections 6 91.68 High High
Hepatotoxicity 6 91.00 High High
Osteoporosis 22 90.28 High High
Acute Chest Syndrome 35 87.04 High High
Aging 49 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both acetyl-CoA carboxylases (ACC1 and ACC2) and stearoyl-CoA desaturase (SCD-1) are activated in the insulin resistant liver.
Positive_regulation (activated) of stearoyl-CoA desaturase in liver
1) Confidence 0.48 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.39 Pain Relevance 0
Both acetyl-CoA carboxylases (ACC1 and ACC2) and stearoyl-CoA desaturase (SCD-1) are activated in the insulin resistant liver.
Positive_regulation (activated) of SCD-1 in liver
2) Confidence 0.48 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.39 Pain Relevance 0
We also observed age-related increases in Scd1 and Osbpl1a, and a progressive decrease in Ppara, all of which influence lipid and insulin signaling [69], [70], [71].
Positive_regulation (increases) of Scd1
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0.79 Pain Relevance 0.04
By using comparative studies, we have demonstrated that SCD-1 is not induced in non-regenerating rubrospinal or Clarke's nucleus neurons suggesting a significant role for successful neuronal regeneration (Breuer et al., submitted for publication).
Neg (not) Positive_regulation (induced) of SCD-1 in neurons
4) Confidence 0.32 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0 Pain Relevance 0.05
This latter possibility is further supported by the increase in stearoyl-CoA desaturase index in PiT1neo/neo mice.
Positive_regulation (increase) of stearoyl-CoA desaturase
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2818845 Disease Relevance 0.05 Pain Relevance 0
SCD-1 is induced in regenerating facial nucleus neurons, but not in non-regenerating neurons of red and Clarke's nucleus.
Neg (not) Positive_regulation (induced) of SCD-1 in neurons
6) Confidence 0.22 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC161801 Disease Relevance 0 Pain Relevance 0
The trabecular bone density of gonadectomized mice fed SCD was significantly increased as compared with sham opereated mice given LCD in both genders (Figure 3).
Positive_regulation (increased) of SCD in trabecular bone
7) Confidence 0.19 Published 2009 Journal Nutr J Section Body Doc Link PMC2711110 Disease Relevance 0.09 Pain Relevance 0
Rees et al [39] found that, compared with control individuals, plasma nitrite (NO2-) levels are elevated in SCD patients during crisis; however, these levels were not significantly different from those in SCD patients at baseline.
Positive_regulation (elevated) of SCD in plasma associated with sickle cell anemia
8) Confidence 0.11 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 1.07 Pain Relevance 0.08
Based upon the respective volumes of distribution calculated for both antibodies from plasma kinetic data, there is a ten-fold increase in the apparent tissue distribution of the cationized F(ab?)
Positive_regulation (increase) of ab in plasma
9) Confidence 0.02 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.26 Pain Relevance 0.03
Here, we investigated the influence of primary afferent nerve fibers, SP, and NK-1 receptor antagonists on hepatocyte apoptosis in vivo induced by administration of activating anti-CD95 monoclonal antibody (mAb) to mice.
Positive_regulation (activating) of mAb in hepatocyte associated with antagonist, primary afferent fibers, apoptosis and substance p
10) Confidence 0.00 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14617692 Disease Relevance 0.73 Pain Relevance 0.61

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