INT114507

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 7.24
Pain Relevance 15.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) cytoplasm (NAV1)
Anatomy Link Frequency
nodes 4
nerve 2
proximal 2
cleavage 2
brain 2
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 475 100.00 Very High Very High Very High
Nav1.7 338 100.00 Very High Very High Very High
nav1.8 68 100.00 Very High Very High Very High
Nav1.2 27 100.00 Very High Very High Very High
nav1.3 25 100.00 Very High Very High Very High
Neuropathic pain 97 99.40 Very High Very High Very High
anticonvulsant 14 99.30 Very High Very High Very High
Pain 400 99.04 Very High Very High Very High
Face pain 11 99.00 Very High Very High Very High
Nav1.1 22 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 119 99.40 Very High Very High Very High
Facial Pain 11 99.00 Very High Very High Very High
Toothache 13 97.16 Very High Very High Very High
Reprotox - General 1 6 96.68 Very High Very High Very High
Brain Tumor 1 96.52 Very High Very High Very High
Pain 341 95.80 Very High Very High Very High
Stroke 12 95.80 Very High Very High Very High
INFLAMMATION 81 95.56 Very High Very High Very High
Inflammatory Pain 23 95.12 Very High Very High Very High
Erythermalgia 7 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transition from the immature to a mature differentiation state, however, was accompanied by the down-regulation of Nav1.7 expression concomitant with the up-regulation of voltage-gated Kv1.3 K+ channel expression.
Negative_regulation (down-regulation) of Gene_expression (expression) of Nav1 associated with nav1.7
1) Confidence 0.43 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19748986 Disease Relevance 0 Pain Relevance 0.23
These results demonstrate the expression of Nav1.5 in human astrocytes and show that Nav1.5 expression is dynamic in these cells.
Negative_regulation (dynamic) of Gene_expression (expression) of Nav1 in astrocytes
2) Confidence 0.43 Published 2010 Journal Brain Section Abstract Doc Link 20147455 Disease Relevance 0.57 Pain Relevance 0.89
A recent investigation in trigeminal neuralgia, a neuropathic pain condition, demonstrated that Nav1.7 levels were decreased.
Negative_regulation (decreased) of Gene_expression (levels) of Nav1 associated with face pain, neuropathic pain and nav1.7
3) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 1.56 Pain Relevance 2.30
The specimens stained with the Nav1.7/N52/PGP9.5 antibodies were used to evaluate Nav1.7 expression within N52 and PGP9.5 identified nerve fibers.
Negative_regulation (evaluate) of Gene_expression (expression) of Nav1 in nerve associated with nav1.7
4) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.57
Therefore, evaluations of Nav1.7 expression within both normal and painful pulpal samples may be useful to further our understanding regarding the role of Nav1.7 to both peripheral human inflammatory and neuropathic pain mechanisms.
Negative_regulation (evaluations) of Gene_expression (expression) of Nav1 associated with pain, inflammation, neuropathic pain and nav1.7
5) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 1.79 Pain Relevance 2.37
This suggests that the reduced expression of Nav1.5 already diminishes the safety factor for conduction, and consequently, TTX selectively aggravates conduction in this AV nodal region.
Negative_regulation (reduced) of Gene_expression (expression) of Nav1 associated with tetrodotoxin
6) Confidence 0.41 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857368 Disease Relevance 0.45 Pain Relevance 0.33
For example, high expression of Nav1.3 during embryonic periods (Albrieux et al. 2004) diminishes as expression of Nav1.2 increases in early postnatal periods in rodents (Felts et al. 1997), and expression of Nav1.2 at immature nodes of Ranvier is replaced by Nav1.6 as myelination proceeds (Boiko et al. 2001; Jenkins and Bennett 2002).
Negative_regulation (diminishes) of Gene_expression (expression) of Nav1 in nodes associated with nav1.3, nav1.2 and nav1.6
7) Confidence 0.41 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1277854 Disease Relevance 0.06 Pain Relevance 0.88
For example, high expression of Nav1.3 during embryonic periods (Albrieux et al. 2004) diminishes as expression of Nav1.2 increases in early postnatal periods in rodents (Felts et al. 1997), and expression of Nav1.2 at immature nodes of Ranvier is replaced by Nav1.6 as myelination proceeds (Boiko et al. 2001; Jenkins and Bennett 2002).
Negative_regulation (diminishes) of Gene_expression (expression) of Nav1 in nodes associated with nav1.3, nav1.2 and nav1.6
8) Confidence 0.41 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1277854 Disease Relevance 0.05 Pain Relevance 0.87
In addition, BPBTS was two orders of magnitude more potent than the clinically used anticonvulsant and antiarrhythmic Nav1 blockers, inhibiting the inactivated state of Nav1.8, Nav1.7, Nav1.5, and Nav1.2, with Ki values of 0.09, 0.15, 0.08, and 0.14 ?
Negative_regulation (inhibiting) of Gene_expression (state) of Nav1 associated with nav1.2, nav1.8, anticonvulsant and nav1.7
9) Confidence 0.38 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2346569 Disease Relevance 0 Pain Relevance 0.54
In addition, BPBTS was two orders of magnitude more potent than the clinically used anticonvulsant and antiarrhythmic Nav1 blockers, inhibiting the inactivated state of Nav1.8, Nav1.7, Nav1.5, and Nav1.2, with Ki values of 0.09, 0.15, 0.08, and 0.14 ?
Negative_regulation (inhibiting) of Gene_expression (state) of Nav1 associated with nav1.2, nav1.8, anticonvulsant and nav1.7
10) Confidence 0.38 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2346569 Disease Relevance 0 Pain Relevance 0.54
In addition, BPBTS was two orders of magnitude more potent than the clinically used anticonvulsant and antiarrhythmic Nav1 blockers, inhibiting the inactivated state of Nav1.8, Nav1.7, Nav1.5, and Nav1.2, with Ki values of 0.09, 0.15, 0.08, and 0.14 ?
Negative_regulation (inhibiting) of Gene_expression (state) of Nav1 associated with nav1.2, nav1.8, anticonvulsant and nav1.7
11) Confidence 0.38 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2346569 Disease Relevance 0 Pain Relevance 0.54
In addition, BPBTS was two orders of magnitude more potent than the clinically used anticonvulsant and antiarrhythmic Nav1 blockers, inhibiting the inactivated state of Nav1.8, Nav1.7, Nav1.5, and Nav1.2, with Ki values of 0.09, 0.15, 0.08, and 0.14 ?
Negative_regulation (inhibiting) of Gene_expression (state) of Nav1 associated with nav1.2, nav1.8, anticonvulsant and nav1.7
12) Confidence 0.38 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2346569 Disease Relevance 0 Pain Relevance 0.54
Similarly, tricyclic antidepressants, such as amitriptyline, which are efficacious in treating neuropathic pain, possess a broad spectrum of pharmacological activities including inhibition of Nav1 channels.
Negative_regulation (inhibition) of Gene_expression (channels) of Nav1 associated with neuropathic pain, endep and tricyclic antidepressant
13) Confidence 0.38 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2346569 Disease Relevance 0.72 Pain Relevance 1.53
Electrophysiology showed that all compounds functionally block brain type II voltage-gated Na(+) channels (Nav1.2) expressed in Xenopus laevis oocytes.
Negative_regulation (block) of Gene_expression (expressed) of Nav1 in brain associated with nav1.2
14) Confidence 0.30 Published 2003 Journal Mol. Cancer Ther. Section Abstract Doc Link 14617788 Disease Relevance 0.51 Pain Relevance 0.14
This suggests that the reduced expression of Nav1.5 already diminishes the safety factor for conduction, and consequently, TTX selectively aggravates conduction in this AV nodal region.
Negative_regulation (reduced) of Gene_expression (expression) of Nav1 associated with tetrodotoxin
15) Confidence 0.30 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857368 Disease Relevance 0.45 Pain Relevance 0.33
Interestingly, NaV1.7 over-expression could be prevented by pre-treatment with COX-1 and COX-2 inhibitors (ibuprofen, NS-398).
Negative_regulation (prevented) of Gene_expression (expression) of NaV1 associated with cox-2 inhibitor
16) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.07 Pain Relevance 1.49
Therefore, it will be interesting to see whether the blockage of BACE1 cleavage in Nav?
Spec (whether) Negative_regulation (blockage) of Gene_expression (cleavage) of Nav in cleavage associated with sodium channel
17) Confidence 0.27 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.63
2-CTF levels and possibly Nav?
Negative_regulation (possibly) of Gene_expression (levels) of Nav associated with sodium channel
18) Confidence 0.27 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.64
These studies also suggest, that subsites proximal to the scissile bond (S1 and S'1) are more stringent than distal residues which is reflected by the drastic decrease in CTF production in Nav?
Negative_regulation (decrease) of Gene_expression (production) of Nav in proximal associated with sodium channel
19) Confidence 0.27 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3022600 Disease Relevance 0 Pain Relevance 0.55

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