INT114508

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.98
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2) plasma membrane (Gria2) protein complex (Gria2)
Gria2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 89 100.00 Very High Very High Very High
Cannabinoid 54 100.00 Very High Very High Very High
tetrodotoxin 3 99.40 Very High Very High Very High
Ventral tegmentum 102 98.76 Very High Very High Very High
amygdala 2 89.36 High High
Dopamine 44 80.16 Quite High
gABA 11 77.84 Quite High
Glutamate receptor 3 66.04 Quite High
nMDA receptor 4 58.76 Quite High
Eae 2 57.28 Quite High
Disease Link Frequency Relevance Heat
Depression 89 100.00 Very High Very High Very High
Li-fraumeni Syndrome 16 83.80 Quite High
Drug Dependence 6 5.00 Very Low Very Low Very Low
Cannabis Dependence 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Recurrence 4 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
Mental Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TTX blockade, on the other hand, induced a significant down-regulation of GluR2 immunoreactivity, GluR2 gene expression as well as CO activity (P < 0.01 for all).
Positive_regulation (induced) of Negative_regulation (down-regulation) of GluR2 associated with tetrodotoxin
1) Confidence 0.36 Published 2003 Journal J. Neurocytol. Section Abstract Doc Link 14618102 Disease Relevance 0 Pain Relevance 0.37
This hypothesis receives additional support by our findings suggesting that a blockade of GluR2 endocytosis prior to cannabinoid exposure with TAT-GluR2 prevented synaptic depression in vivo, resulting in a blockade of cannabinoid-facilitated in vitro LTD induction in the VTA.
Positive_regulation (facilitated) of Negative_regulation (blockade) of GluR2 associated with ventral tegmentum, depression and cannabinoid
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004941 Disease Relevance 0.98 Pain Relevance 1.27

General Comments

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